Edoardo Tito is a chemical engineer, currently Research Fellow at DISAT within the CREST group (Catalytic Reaction Engineering for Sustainable Technologies). His research activity focuses on (bio)refinery processes aimed at producing materials and energy from organic (biomass) and plastic waste. His main research areas include Hydrothermal Liquefaction (HTL), Aqueous Phase Reforming (APR), and Supercritical Water Gasification (SCWG). Hydrothermal liquefaction enables the efficient conversion of organic waste—particularly wet waste—into advanced biofuels through non-catalytic transformations in a hydrothermal environment at moderate temperatures and high pressures (300–450 °C, 120–250 bar). Under similar conditions, the process is also studied for converting plastic and textile waste into monomers for the petrochemical industry and/or into energy products with properties similar to fossil fuels. The valorization of aqueous streams represents a key element for the overall sustainability of these processes. For this reason, pollutant load reduction and the production of hydrogen and/or methane are investigated under sub- and supercritical hydrothermal conditions through the catalytic processes of APR and SCWG. Across all these research areas, the focus is on understanding the chemical mechanisms underlying the processes, identifying strategies for operational optimization, and integrating them into waste treatment chains, with the goal of generating synergies and improving overall resource recovery efficiency. These aspects are further explored through techno-economic assessments and environmental sustainability analyses, in order to contribute in a technical and objective way to the debate on the sustainability of waste valorization systems.