Dottorato in Bioingegneria E Scienze Medico-chirurgiche , 32o ciclo (2016-2019)
Dottorato concluso nel 2020
Tesi:
Stimuli-responsive poly(ether urethane) hydrogels for the design of smart patient-specific patches in skin wound treatment (Abstract)
Tutori:
Valeria Chiono Monica BoffitoProfilo
Argomento di ricerca
Ad hoc engineered stimuli-responsive hydrogels as inks to 3D-print patient-specific wound dressings
Interessi di ricerca
Biografia
In the same year, Rossella received the qualification for the profession of Industrial Engineer.
After her Master’s Degree, Rossella worked as fellowship researcher in a start-up company dealing with material processing through additive manufacturing processes. Specifically, she focused on the design and fabrication of 3D ad-hoc customised scaffolds and on their biological evaluation in the perspective of wound healing and orthopaedic applications.
From May to October 2016 Rossella worked as pre-PhD-student in the Industrial and Bioengineering group at the Politecnico di Torino under the supervision of Prof V. Chiono and Dr C. Tonda-Turo focusing on the design of naturally-derived hydrogels as bio-inks.
From November 2016 Rossella is a PhD-student in Bioengineering and Medical-Surgical Sciences (XXXII cycle) at the Politecnico di Torino under the supervision of Prof V. Chiono and Dr M. Boffito. Rossella’s research activity mainly focuses on material development and on the design of polyurethane-based hydrogels sensitive to several external stimuli (i.e. temperature and pH changes and light exposure) suitable as drug vehicles or bio-inks.
During her PhD she has been involved in an international project (H2020-NMP6-2015 - MOZART) working on the preparation of a hybrid injectable platform for the co-current release of different therapeutic agents in the treatment of chronic skin wounds and delayed bone healing. Furthermore, she has also collaborated with ERC-CoG 2017 - BIORECAR project coordinated by Prof V. Chiono, designing injectable bioartificial and in situ crosslinkable formulations as drug carriers.
Currently, these activities have produced 9 research papers (6 published, 3 submitted) in international peer reviewed journals, 1 book chapter and 15 conference proceedings. The number of citations has constantly increased over the last three years reaching a maximum of 19 citations in 2019 with an H-index = 3 (SCOPUS).
Settore scientifico discliplinare
(Area 0009 - Ingegneria industriale e dell'informazione)
Didattica
Collegi dei Corsi di Studio
- Collegio di Ingegneria Biomedica. Componente invitato
Insegnamenti
Corso di laurea magistrale
- Sistemi biomimetici. A.A. 2017/18, INGEGNERIA BIOMEDICA. Collaboratore del corso
- Ingegneria per la medicina rigenerativa/Bioreattori (modulo di Ingegneria per la medicina rigenerativa). A.A. 2017/18, INGEGNERIA BIOMEDICA. Collaboratore del corso
- Ingegneria per la medicina rigenerativa/Bioreattori (modulo di Ingegneria per la medicina rigenerativa). A.A. 2018/19, INGEGNERIA BIOMEDICA. Collaboratore del corso
- Ingegneria per la medicina rigenerativa/Bioreattori (modulo di Ingegneria per la medicina rigenerativa). A.A. 2019/20, INGEGNERIA BIOMEDICA. Collaboratore del corso
Corso di laurea di 1° livello
- Bioingegneria chimica/Bioingegneria meccanica (modulo di Bioingegneria chimica). A.A. 2017/18, INGEGNERIA BIOMEDICA. Collaboratore del corso
- Bioingegneria chimica/Bioingegneria meccanica (modulo di Bioingegneria chimica). A.A. 2018/19, INGEGNERIA BIOMEDICA. Collaboratore del corso
- Bioingegneria chimica/Bioingegneria meccanica (modulo di Bioingegneria chimica). A.A. 2019/20, INGEGNERIA BIOMEDICA. Collaboratore del corso
Ricerca
Dottorandi
- Andrea Alliaud. Corso in Bioingegneria E Scienze Medico-chirurgiche (ciclo 38, 2022-in corso)
Argomento della ricerca: Progettazione di modelli tissutali 3D bioingegnerizzati in vitro per analisi di citotossicità
Materials, surfaces and biofabrication techniques for tissue engineering and advanced implants Materials, surfaces and biofabrication techniques for tissue engineering and advanced implants Materials, surfaces and biofabrication techniques for tissue engineering and advanced implants
Pubblicazioni
Coautori PoliTO
Pubblicazioni degli ultimi anni
Pubblicazioni per tipo
Pubblicazioni durante il dottorato Vedi tutte le pubblicazioni su Porto@Iris
- Laurano, Rossella; Boffito, Monica; Chiono, Valeria; Ciardelli, Gianluca (2020)
Polyurethane-based hydrogels as promising drug-loaded coatings for biomedical devices. In: UROLITHIASIS, vol. 48, pp. 556-557. ISSN 2194-7228
Contributo su Rivista - Boffito, Monica; Laurano, Rossella; Giasafaki, Dimitra; Steriotis, Theodore; ... (2020)
Embedding Ordered Mesoporous Carbons into Thermosensitive Hydrogels: A Cutting-Edge Strategy to Vehiculate a Cargo and Control Its Release Profile. In: NANOMATERIALS, vol. 10, pp. 1-24. ISSN 2079-4991
Contributo su Rivista - Zoso, Alice; Boffito, Monica; Laurano, Rossella; Carmagnola, Irene; Chiono, Valeria (2020)
Cell–biomaterial interactions: the role of ligand functionalization. In: Handbook of Biomaterials Biocompatibility / Mozafari M., S.L., Elsevier Woodhead Publishing, pp. 139-173. ISBN: 9780081029688
Contributo in Volume - Laurano, Rossella; Cassino, Claudio; Ciardelli, Gianluca; Chiono, Valeria; Boffito, ... (2020)
Polyurethane-based thiomers: a new multifunctional copolymer platform for biomedical applications. In: REACTIVE & FUNCTIONAL POLYMERS, vol. 146. ISSN 1381-5148
Contributo su Rivista - Boffito, Monica; Torchio, Alessandro; TONDA TURO, Chiara; Laurano, Rossella; ... (2020)
Hybrid Injectable Sol-Gel Systems Based on Thermo-Sensitive Polyurethane Hydrogels Carrying pH-Sensitive Mesoporous Silica Nanoparticles for the Controlled and Triggered Release of Therapeutic Agents. In: FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, vol. 8, pp. 1-24. ISSN 2296-4185
Contributo su Rivista - Laurano, Rossella (2020)
Stimuli-responsive poly(ether urethane) hydrogels for the design of smart patient-specific patches in skin wound treatment. relatore: CHIONO, VALERIA; BOFFITO, MONICA; , 32. XXXII Ciclo, P.: 362
Doctoral Thesis - Laurano, Rossella; Boffito, Monica (2020)
Thermosensitive micellar hydrogels as vehicles to deliver drugs with different wettability. In: FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, vol. 8, pp. 1-14. ISSN 2296-4185
Contributo su Rivista - Laurano, Rossella; Abrami, Michela; Grassi, Mario; Ciardelli, Gianluca; Boffito, Monica; ... (2020)
Using Poloxamer® 407 as Building Block of Amphiphilic Poly(ether urethane)s: Effect of its Molecular Weight Distribution on Thermo-Sensitive Hydrogel Performances in the Perspective of Their Biomedical Application. In: FRONTIERS IN MATERIALS, vol. 7, pp. 1-15. ISSN 2296-8016
Contributo su Rivista - Chiono, Valeria; Laurano, Rossella; Zoso, Alice; Boffito, Monica (2019)
Thermosensitive bioartificial hydrogels as smart injectable and biocompatible systems allowing post-injection chemical crosslinking. In: 30th Annual conference of the European Society for Biomaterials, Dresden (DE), September 9-13, 2019
Contributo in Atti di Convegno (Proceeding) - Boffito, Monica; Laurano, Rossella; Chiono, Valeria; Ciardelli, Gianluca (2019)
Thorough investigation on the encapsulation of drugs with different wettability in thermosensitive micellar hydrogels. In: TERMIS-EU 2019, Rhodes (Greece), 27-31 May 2019
Contributo in Atti di Convegno (Proceeding) - Laurano, Rossella; Boffito, Monica; Torchio, Alessandro; Cassino, Claudio; Chiono, ... (2019)
Plasma treatment of polymer powder as an effective tool to functionalize polymers: case study application on an amphiphilic polyurethane. In: POLYMERS, vol. 11. ISSN 2073-4360
Contributo su Rivista - Laurano, Rossella; Boffito, Monica; Abrami, Michela; Grassi, Mario; Ciardelli, Gianluca; ... (2019)
Design of polyurethane-based temperature- and pH-responsive hydrogels. In: TERMIS-EU 2019, Rhodes (Greece), 27-31 May 2019
Contributo in Atti di Convegno (Proceeding) - Boffito, Monica; Pontremoli, Carlotta; Fiorilli, SONIA LUCIA; Laurano, Rossella; ... (2019)
Injectable thermosensitive formulation based on polyurethane hydrogel/mesoporous glasses for sustained co-delivery of functional ions and drugs. In: PHARMACEUTICS, vol. 11, pp. 1-20. ISSN 1999-4923
Contributo su Rivista - Pontremoli, C.; Boffito, M.; Fiorilli, S.; Laurano, R.; Torchio, A.; Bari, A.; ... (2018)
Hybrid injectable platforms for the in situ delivery of therapeutic ions from mesoporous glasses. In: CHEMICAL ENGINEERING JOURNAL, vol. 340, pp. 103-113. ISSN 1385-8947
Contributo su Rivista - Laurano, Rossella; Torchio, Alessandro; Boffito, Monica; Ciardelli, Gianluca (2017)
Injectable polyurethane-based hydrogels for smart drug release in the treatment of chronic skin wounds. In: iSMIT 2017, Torino (Italy), 9-10 November 2017
Contributo in Atti di Convegno (Proceeding)