Dottorato in Ingegneria Chimica , 32o ciclo (2016-2019)
Dottorato concluso nel 2020
Tesi:
Freeze Drying of Therapeutic Proteins: A Simulation Approach to Optimize Formulation and Process Conditions (Abstract)
Tutori:
Roberto Pisano Antonello Barresi
Presentazione della ricerca:
PosterProfilo
Argomento di ricerca
Liofilizzazione di farmaci a base proteica: Simulazioni per ottimizzare formulazione e processo
Interessi di ricerca
Biografia
Premi e riconoscimenti
- premio miglior poster alla protein stability conference 2019 in Colorado (2019)
- Introductory Certificate in Project Management (2018)
- L'articolo "Application of the Quality by Design approach to the freezing step of freeze-drying: building the design space" è selezionato come 'featured article' dagli editori della rivista perchè ritenuto originale e significativo da un punto di vista scientifico. (2018)
- Legacy BioDesign LLC seleziona l'articolo 'Water Entrapment and Structure Ordering as Protection Mechanisms for Protein Structural Preservation' come particolarmente rilevante per gli esperti di formulazione e sviluppo di processo, e ne include una breve descrizione nella rivista 'Staying Current: Formulation of Biopharmaceuticals' (2018)
- Advances in Engineering seleziona l'articolo 'Clarifying the role of cryo- and lyo-protectants in the biopreservation of proteins' per il suo originale contenuto scientifico, e decide di dedicarvi un breve contributo. (2018)
Didattica
Insegnamenti
Corso di laurea di 1° livello
- Controllo, strumentazione e sicurezza per i processi chimici (modulo di Controllo e strumentazione per i processi chimici). A.A. 2018/19, INGEGNERIA CHIMICA E ALIMENTARE. Collaboratore del corso
Pubblicazioni
Pubblicazioni durante il dottorato Vedi tutte le pubblicazioni su Porto@Iris
- Arsiccio, A.; Ganguly, P.; La Cortiglia, L.; Shea, J. -E.; Pisano, R. (2020)
ADD force field for sugars and polyols: predicting the additivity of protein-osmolyte interaction. In: JOURNAL OF PHYSICAL CHEMISTRY. B, CONDENSED MATTER, MATERIALS, SURFACES, INTERFACES & BIOPHYSICAL, vol. 124, pp. 7779-7790. ISSN 1520-6106
Contributo su Rivista - Arsiccio, A.; Giorsello, P.; Marenco, L.; Pisano, R. (2020)
Considerations on protein stability during freezing and its impact on the freeze-drying cycle: a design space approach. In: JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 109, pp. 464-475. ISSN 0022-3549
Contributo su Rivista - Arsiccio, Andrea (2020)
Freeze Drying of Therapeutic Proteins: A Simulation Approach to Optimize Formulation and Process Conditions. relatore: PISANO, ROBERTO; BARRESI, Antonello; , 32. XXXII Ciclo, P.: 286
Doctoral Thesis - Arsiccio, A.; Marenco, L.; Pisano, R. (2020)
A model-based approach for the rational design of the freeze-thawing of a protein-based formulation. In: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, vol. 25, pp. 823-831. ISSN 1083-7450
Contributo su Rivista - Arsiccio, A.; Pisano, R. (2020)
The ice-water interface and protein stability: a review. In: JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 109, pp. 2116-2130. ISSN 0022-3549
Contributo su Rivista - Arsiccio, A.; Matejtschuk, P.; Ezeajughi, E.; Riches-Duit, A.; Bullen, A.; Malik, K.; ... (2020)
Impact of controlled vacuum induced surface freezing on the freeze drying of human plasma. In: INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 582. ISSN 0378-5173
Contributo su Rivista - Oddone, I.; Arsiccio, A.; Duru, C.; Malik, K.; Ferguson, J.; Pisano, R.; Matejtschuk, P. (2020)
Vacuum-induced surface freezing for the freeze-drying of the Human Growth Hormone: how does nucleation control affect protein stability?. In: JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 109, pp. 254-263. ISSN 0022-3549
Contributo su Rivista - Arsiccio, Andrea; Mccarty, James; Shea, Joan-Emma; Pisano, Roberto (2019)
Surface-driven denaturation of proteins during freeze-drying: An insight into the role of surfactants. In: 9th International Symposium on Lyophilization of Pharmaceuticals, Ghent, September 2-6, 2019, pp. 41-42
Contributo in Atti di Convegno (Proceeding) - Arsiccio, Andrea; Pisano, Roberto (2019)
A design space approach for the freezing step of freeze-drying: considerations for process performance and protein stability. In: 7th European Conference “EuroDrying’2019”, Torino, July 10-12, 2019
Contributo in Atti di Convegno (Proceeding) - Arsiccio, Andrea; Mccarty, James; Shea, Joan-Emma; Pisano, Roberto (2019)
Effect of Surfactants on Surface-Induced Denaturation of Proteins: An Insight from Molecular Dynamics. In: 2019 Colorado Protein Stability Conference - 25th Anniversary, Breckenridge, Colorado, USA, July 29 - August 1
Contributo in Atti di Convegno (Proceeding) - Arsiccio, Andrea; Pisano, Roberto (2019)
Rational design of freeze-drying formulations: a molecular dynamics approach. In: 7th European Conference “EuroDrying’2019”, Torino, July 10-12, 2019
Contributo in Atti di Convegno (Proceeding) - Pisano, R.; Arsiccio, A.; Nakagawa, K.; Barresi, A. A. (2019)
Tuning, measurement and prediction of the impact of freezing on product morphology: A step toward improved design of freeze-drying cycles. In: DRYING TECHNOLOGY, vol. 37, pp. 579-599. ISSN 0737-3937
Contributo su Rivista - Arsiccio, Andrea; Pisano, Roberto (2019)
Rational design of freeze-drying formulations: A Molecular Dynamics approach. In: 9th International Symposium on Lyophilization of Pharmaceuticals, Ghent, September 2-6, 2019, pp. 55-56
Contributo in Atti di Convegno (Proceeding) - Arsiccio, A.; Sparavigna, A. C.; Barresi, A. A. (2019)
Image segmentation applied to the investigation of craquelure domains in paintings. In: 7th European Drying Conference, Torino, 10-12 July 2019, pp. 547-554
Contributo in Atti di Convegno (Proceeding) - Arsiccio, A.; Sparavigna, A. C.; Pisano, R.; Barresi, A. A. (2019)
Measuring and predicting pore size distribution of freeze-dried solutions. In: DRYING TECHNOLOGY, vol. 37, pp. 435-447. ISSN 0737-3937
Contributo su Rivista