Ph.D. in Bioingegneria E Scienze Medico-chirurgiche , 36^th cycle (2020-2023)

Ph.D. obtained in 2024

Dissertation:

Fused deposition modelling supporting the design of in vitro models of diseased muscular tissues (Abstract)

Tutors:

Valeria Chiono Irene Carmagnola

Profile

Research topic

Development of biomimetic scaffolds for in vitro modelling and tissue regeneration

Research interests

Medical Innovation and Technology

Nanomedicine

Bionanotechnology

Cardiovascular Engineering

Micro-, meso- and nanostructured materials for advanced therapies

Materials, surfaces and biofabrication techniques for tissue engineering and advanced implants

Biography

I have a Master Degree in Biomedical Engineering and I am currently a PhD student in Bioengineering and MedicalSurgical Science at Politecnico di Torino, Italy. My research consists of the design of biomimetic scaffolds by rapid prototyping methods and their functionalization to guide cell behaviour for tissue regeneration and in vitro modelling. In more detail, I worked on design of in vitro models of human tissue, such as heart scar tissue, esophageus epitelium tissue and muscler tissue, based on bioartificial scaffolds and cellularised hydrogels. I also conducted part of my research in UKE, Hamburg, in thepharmacology and toxicology department, working on the development of a mecanical stimulation sistem to induce pathological condition on human in vitro model of cardiac tissue. During my PhD i worked mostly on coupling and designing materials to trigger cells behaviour to reproduce specific condition. I worked both with synthetic and natural material. I used mainly melt extrusion additive manufacturing to produce polycaprolactone (PCL) based scaffold, eventualy surface functionalized, and copupled with cellularized hydrogel such asgelatin meacryloyl (GelMA).

Awards and Honors

Award for “Best oral presentation” at Fourth Centro 3R Annual Meeting - The role of 3Rs in the age of One Health: where we are and where we’re going, Sep 13-15, 2023, Milan (Italy) for the work “In vitro model of the human esophageal epithelium by tissue engineering tools” (2023)
Best poster presentation presso Winter School of Bioprinting, Università di Pavia. (2020)

Teaching

Teachings

Master of Science

Ingegneria per la medicina rigenerativa. A.A. 2020/21, INGEGNERIA BIOMEDICA. Collaboratore del corso
Ingegneria per la medicina rigenerativa. A.A. 2021/22, INGEGNERIA BIOMEDICA. Collaboratore del corso
Ingegneria per la medicina rigenerativa/Bioreattori (modulo di Ingegneria per la medicina rigenerativa). A.A. 2022/23, INGEGNERIA BIOMEDICA. Collaboratore del corso
Ingegneria per la medicina rigenerativa/Bioreattori (modulo di Ingegneria per la medicina rigenerativa). A.A. 2023/24, INGEGNERIA BIOMEDICA. Collaboratore del corso
Laboratory of Tissues and Physiological Processes' Models. A.A. 2021/22, INGEGNERIA BIOMEDICA. Collaboratore del corso
Laboratory of Tissues and Physiological Processes' Models. A.A. 2022/23, INGEGNERIA BIOMEDICA. Collaboratore del corso
Laboratory of Tissues and Physiological Processes' Models. A.A. 2023/24, INGEGNERIA BIOMEDICA. Collaboratore del corso

MostraNascondi A.A. passati

Research

Research groups

Materials in bionanotechnology and biomedical lab

Publications

Works published during the Ph.D. View all publications in Porto@Iris

Spedicati, Mattia (2024)
Fused deposition modelling supporting the design of in vitro models of diseased muscular tissues. relatore: CHIONO, VALERIA; CARMAGNOLA, IRENE; , 36. XXXVI Ciclo, P.: 276
Doctoral Thesis
Spedicati, Mattia; Zoso, Alice; Mortati, Leonardo; Chiono, Valeria; Marcello, Elena; ... (2024)
Three-Dimensional Microfibrous Scaffold with Aligned Topography Produced via a Combination of Melt-Extrusion Additive Manufacturing and Porogen Leaching for In Vitro Skeletal Muscle Modeling. In: BIOENGINEERING, vol. 11. ISSN 2306-5354
Contributo su Rivista
Spedicati, Mattia; Zoso, Alice; Mortati, Leonardo; Chiono, Valeria; Marcello, Elena; ... (2024)
3D Aligned Microfibrous Scaffold for Skeletal Muscle Modeling. In: SIB 2024, Faenza (IT)
Contributo in Atti di Convegno (Proceeding)
Spedicati, Mattia; Tivano, Francesca; Zoso, Alice; Bei, Janira; Lavella, Mario; ... (2024)
3D bioartificial stretchable scaffolds mimicking the mechanical hallmarks of human cardiac fibrotic tissue. In: INTERNATIONAL JOURNAL OF BIOPRINTING. ISSN 2424-8002
Contributo su Rivista
Spedicati, M.; Zoso, A.; Carmagnola, I.; Chiono, V. (2023)
In vitro model of the human esophageal epithelium by tissue engineering tools. In: Fourth Centro 3R Annual Meeting - The role of 3Rs in the age of One Health: where we are and where we’re going, Milano (IT)
Contributo in Atti di Convegno (Proceeding)
Spedicati, Mattia; Carmagnola, Irene; Lavella, Mario; Tivano, Francesca; Zoso, Alice; ... (2023)
3D Melt-fabricated bio-hybrid scaffolds for the in vitro modelling of human cardiac fibrosis. In: ESB2023 Conference - Davos
Contributo in Atti di Convegno (Proceeding)
Zoso, A.; Tivano, F.; Spedicati, M.; Lavella, M.; Carmagnola, I.; Chiono, V. (2023)
3D In Vitro Modelling Of Human Cardiac Fibrotic Tissue Through Bio-hybrid Stretchable Scaffolds. In: 7th TERMIS World Congress, Seattle, WA (USA), June 25–28, 2024
Contributo in Atti di Convegno (Proceeding)
Tivano, Francesca; Spedicati, Mattia; Zoso, Alice; Bei, Janira; Lavella, Mario; ... (2022)
3D bioartificial stretchable scaffolds for an in vitro model of fibrotic cardiac tissue. In: International Conference on Biofabrication 2022, Montecatini-Terme (IT), September 25th -28th 2022
Contributo in Atti di Convegno (Proceeding)
Tivano, Francesca; Spedicati, Mattia; Zoso, Alice; Lavella, Mario; Carmagnola, Irene; ... (2022)
3D bioartificial stretchable scaffolds for an in vitro model of fibrotic cardiac tissue. In: 32nd Annual Conference of the European Society for Biomaterials (ESB), Bordeaux, 4 – 8 September 2022
Contributo in Atti di Convegno (Proceeding)
Spedicati, Mattia; Ruocco, Gerardina; Zoso, Alice; Mortati, Leonardo; Lapini, Andrea; ... (2022)
Biomimetic design of bioartificial scaffolds for the in vitro modelling of human cardiac fibrosis. In: FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, vol. 10. ISSN 2296-4185
Contributo su Rivista
Spedicati, Mattia; Carmagnola, Irene; Zoso, Alice; Ruocco, Gerardina; Chiono, Valeria (2021)
3D IN VITRO MODELS OF EARLY AND LATE HUMAN CARDIAC FIBROSIS BY TUNING 3D ARCHITECTURE OF BIOARTIFICIAL SCAFFOLDS. In: Termis 6th world congress, Maastricht (NL), 15-19 novembre 2021, pp. 140-140
Contributo in Atti di Convegno (Proceeding)
Spedicati, Mattia; Carmagnola, Irene; Zoso, Alice; Ruocco, Gerardina; Chiono, Valeria (2021)
3D In Vitro Model of Early-Stage Human Cardiac Fibrosis Based on Bioartificial Scaffold. In: Cell-Matrix Interaction and Mechanobiology in Regenerative Medicine, BRNO (CZ), 10-11 giugno 2021, pp. 36-36
Contributo in Atti di Convegno (Proceeding)
Spedicati, Mattia; Ruocco, Gerardina; Zoso, Alice; Carmagnola, Irene; Chiono, Valeria (2020)
In vitro models of fibrotic cardiac tissue as a potential tool for testing cardioprotective therapies for cardiovascular diseases related to COVID-19. In: Virtual FISV Symposium on SARS-CoV-2 Biology and COVID-19: Current research and perspectives. ISBN: 978-88-943891-2-8
Contributo in Atti di Convegno (Proceeding)
Spedicati, Mattia; Ruocco, Gerardina; Zoso, Alice; Carmagnola, Irene; Chiono, Valeria (2020)
In vitro models of human pathological cardiac tissue via bioartificial scaffolds. In: Winter School of Bioprinting: From 3D printing set-up to lab analysis, Università di Pavia, Pavia
Contributo in Atti di Convegno (Proceeding)
Carmagnola, Irene; Zoso, Alice; Spedicati, Mattia; Ruocco, Gerardina; Chiono, Valeria (2020)
Tissue-engineered models of human pathological cardiac tissue through bioartificial scaffolds. In: 11TH World Biomaterials Congress, virtuale, 11 - 15 December 2020
Contributo in Atti di Convegno (Proceeding)
Spedicati, Mattia; Ruocco, Gerardina; Zoso, Alice; Carmagnola, Irene; Chiono, Valeria (2020)
Design of in vitro model of fibrotic cardiac tissue. In: Trainee Symposium for Organoids & Organs-on-a-chip, Online Webinar, 11/08/2020
Contributo in Atti di Convegno (Proceeding)
Carmagnola, Irene; Zoso, Alice; Paoletti, Camilla; Tarricone, Giulia; Spedicati, Mattia; ... (2020)
Biomimetic scaffolds and multifunctional materials in the regeneration of pathological cardiac tissue. In: NICE – 2020 International Conference, Nizza (FR), October 12 – 14, 2020
Contributo in Atti di Convegno (Proceeding)
Zoso, Alice; Carmagnola, Irene; Ruocco, Gerardina; Spedicati, Mattia; Chiono, Valeria (2020)
In vitro models of human cardiac fibrotic tissue on ‘bioartificial’ scaffolds. In: BIOMEDICAL SCIENCE AND ENGINEERING, vol. 3, pp. 35-35. ISSN 2531-9892
Contributo su Rivista

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Mattia Spedicati

Ph.D. in Bioingegneria E Scienze Medico-chirurgiche , 36th cycle (2020-2023)