Marcello Miceli

Ph.D. in Bioingegneria E Scienze Medico-chirurgiche , 36^th cycle (2020-2023)

Ph.D. obtained in 2024

Dissertation:

Insights Into the Molecular Mechanisms Driving Rare Neurodegenerative Diseases and Therapeutic Strategies Aided By In Silico Modelling (Abstract)

Tutors:

Umberto Morbiducci Marco Agostino Deriu

Profile

Research topic

Study of pathophysiological mechanisms underlying the development of neurodegenerative diseases

Research interests

Multiscale Modelling Methods in Biomechanics

Biography

Marcello Miceli was born in Avola (SR) on 15th February 1994. He graduated MSc cum laude in Biomedical Engineering at Politecnico di Torino in July 2019, major in “Biomedical instrumentation”. He is currently a PhD student at Politecncio di Torino, his research project is titled « Study of pathophysiological mechanisms underlying the development of neurological and/or neurodegenerative diseases using molecular and multiscale modelling methods »

Awards and Honors

Cover art: Journal of Medicinal Chemistry, Vol. 64 N. 21, related to the publication “Noncovalent Interactions with PAMAM and PPI Dendrimers Promote the Cellular Uptake and Photodynamic Activity of Rose Bengal: The Role of the Dendrimer Structure” doi.org/10.1021/acs.jmedchem.1c01080 (2021)

Teaching

Teachings

Master of Science

Biomechanical design. A.A. 2021/22, INGEGNERIA BIOMEDICA. Collaboratore del corso
Biomechanical design. A.A. 2022/23, INGEGNERIA BIOMEDICA. Collaboratore del corso
Rational Drug Design: Principles and Applications. A.A. 2021/22, INGEGNERIA BIOMEDICA. Collaboratore del corso
Rational Drug Design: Principles and Applications. A.A. 2022/23, INGEGNERIA BIOMEDICA. Collaboratore del corso
Rational Drug Design: Principles and Applications. A.A. 2023/24, INGEGNERIA BIOMEDICA. Collaboratore del corso
Biomeccanica multiscala. A.A. 2021/22, INGEGNERIA BIOMEDICA. Collaboratore del corso
Biomeccanica multiscala. A.A. 2022/23, INGEGNERIA BIOMEDICA. Collaboratore del corso
Biomeccanica multiscala. A.A. 2023/24, INGEGNERIA BIOMEDICA. Collaboratore del corso

MostraNascondi A.A. passati

Research

Research groups

Solid and fluid biomechanics

Publications

PoliTO co-authors

Last years publications

Publications by type

Works published during the Ph.D. View all publications in Porto@Iris

Miceli, Marcello (2024)
Insights Into the Molecular Mechanisms Driving Rare Neurodegenerative Diseases and Therapeutic Strategies Aided By In Silico Modelling. relatore: MORBIDUCCI, UMBERTO; DERIU, MARCO AGOSTINO; , 36. XXXVI Ciclo, P.: 258
Doctoral Thesis
Cannariato, Marco; Zizzi, Eric Adriano; Pallante, Lorenzo; Miceli, Marcello; Deriu, ... (2023)
Mechanical communication within the microtubule through network‑based analysis of tubulin dynamics. In: BIOMECHANICS AND MODELING IN MECHANOBIOLOGY. ISSN 1617-7959
Contributo su Rivista
Cannariato, Marco; Miceli, Marcello; Cavaglià, Marco; Deriu, Marco A. (2022)
Prediction of Protein–Protein Interactions Between Alsin DH/PH and Rac1 and Resulting Protein Dynamics. In: FRONTIERS IN MOLECULAR NEUROSCIENCE, vol. 14. ISSN 1662-5099
Contributo su Rivista
Cannariato, Marco; Miceli, Marcello; Deriu, MARCO AGOSTINO (2022)
In silico investigation of Alsin RLD conformational dynamics and phosphoinositides binding mechanism. In: PLOS ONE, vol. 17, pp. 1-15. ISSN 1932-6203
Contributo su Rivista
Miceli, Marcello; Exertier, Cécile; Cavaglià, Marco; Gugole, Elena; Boccardo, Marta; ... (2022)
ALS2-Related Motor Neuron Diseases: From Symptoms to Molecules. In: BIOLOGY, vol. 11. ISSN 2079-7737
Contributo su Rivista
Zizzi, Eric A.; Pallante, Lorenzo; Miceli, Marcello; Sztandera, Krzysztof; Batal, ... (2021)
PAMAM and PPI dendrimers as potential anti-cancer drug carriers: a computational investigation. In: CANCERTO - NANOSCIENCE IN CANCER IMMUNOTHERAPY, March 9–11, 2021. ISBN: 978-2-88966-543-3
Contributo in Atti di Convegno (Proceeding)
Sztandera, Krzysztof; Gorzkiewicz, Michal; Sofia Dias Martins, Ana; Pallante, Lorenzo; ... (2021)
Noncovalent Interactions with PAMAM and PPI Dendrimers Promote the Cellular Uptake and Photodynamic Activity of Rose Bengal: The Role of the Dendrimer Structure. In: JOURNAL OF MEDICINAL CHEMISTRY. ISSN 0022-2623
Contributo su Rivista
Miceli, Marcello; Exertier, Cecile; Vallone, Beatrice; Cavaglià, Marco; Deriu, Marco A. (2021)
Elucidating molecular connetion between IAHSP onset and Alsin protein by means of Homology Modelling and Molecular Dynamics. In: III Convegno Annuale "L'era delle 3R: modelli in silico, in vitro e in vivo per promuovere la ricerca traslazionale". ISSN 2531-9892
Contributo in Atti di Convegno (Proceeding)
Pallante, Lorenzo; Zizzi, ERIC ADRIANO; Miceli, Marcello; Grasso, Gianvito; Huczynski, ... (2021)
Understanding the molecular binding mechanism of colchicine derivatives targeting bIII human tubulin isotype. In: CANCERTO - NANOSCIENCE IN CANCER IMMUNOTHERAPY, March 9–11, 2021. ISBN: 978-2-88966-543-3
Contributo in Atti di Convegno (Proceeding)
Miceli, Marcello; Muscat, Stefano; Morbiducci, Umberto; Cavaglia', Marco; Deriu, MARCO ... (2021)
ULTRASOUND DRIVEN AMYLOID FIBRIL UNFOLDING INVESTIGATED BY MOLECULAR MODELLING. In: 26th Congress of the European Society of Biomechanics, Milan (IT), July 11-14, 2021, pp. 206-206
Contributo in Atti di Convegno (Proceeding)

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