Dottorato in Ingegneria Elettrica, Elettronica E Delle Comunicazioni , 32o ciclo (2016-2019)
Dottorato concluso nel 2020
Tesi:
Study of a new ultrasound-based device in combination with smart nanoparticles for the treatment of cancer (Abstract)
Tutori:
Valentina Alice Cauda Candido PirriProfilo
Argomento di ricerca
Study of ultrasound-based devices in combination with smart nanoparticles for cancer therapy
Interessi di ricerca
Biografia
I graduated in Cellular and Molecular Biology at the University of Turin in April 2015, where I spent almost two years studying the combination of modified gold nanoparticles and ultrasounds on cancer cells. In that period I had the chance to appreciate the advantages and the challenges of the research, and I began to be interested in nanodevices employed for the treatment of human and animal pathologies.
Now I am doing the PhD in Electrical, Electronics and Communications Engineering at Politecnico of Turin, where I work in TNH Lab. My activity is focused on the study of the synergistic effects of ultrasound and shock waves, generated by different devices, and ZnO nanocrystals for the treatment of human carcinomas.
Premi e riconoscimenti
- Patent: “Sonosensitizing agent and its method of activation” (Original title:“Agente sonosensibilizzante e suo metodo di attivazione”) application n.P3008IT00 (2019)
- “A biomimetic nanoporous carrier comprising an inhibitor directed towards the native form of IDH2 protein” (Original title: “Vettore nanoporoso biomimetico comprendente un inibitore diretto verso la forma nativa della proteina IDH2”) Italian Patent N. IT102019000001009 (2019)
- Patent: NON-IMMUNOGENIC NANOASSEMBLY FOR THE ANTITUMOR THERAPY (2019)
- Best Poster Award at the Merck Young Chemical Symposium 2016 (MYCS, Rimini, 25-27th October) (2019)
Pubblicazioni
Pubblicazioni durante il dottorato Vedi tutte le pubblicazioni su Porto@Iris
- Racca, Luisa; Limongi, Tania; Vighetto, Veronica; Dumontel, Bianca; Ancona, Andrea; ... (2020)
Zinc Oxide Nanocrystals and High-Energy Shock Waves: A New Synergy for the Treatment of Cancer Cells. In: FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, vol. 8. ISSN 2296-4185
Contributo su Rivista - Cauda, VALENTINA ALICE; Canavese, Giancarlo; Limongi, Tania; Garino, Nadia; Laurenti, ... (2020)
BIOMIMETIC NON - IMMUNOGENIC NANOASSEMBLY FOR THE ANTITUMOR THERAPY. N. brevetto: US 20200330616A1, propr. brevetto: Politecnico di Torino
Brevetti - Racca, Luisa (2020)
Study of a new ultrasound-based device in combination with smart nanoparticles for the treatment of cancer. relatore: CAUDA, VALENTINA ALICE; PIRRI, Candido; , 32. XXXII Ciclo, P.: 176
Doctoral Thesis - Vighetto, V.; Ancona, A.; Racca, L.; Limongi, T.; Troia, A.; Canavese, G.; Cauda, V. (2019)
The Synergistic Effect of Nanocrystals Combined With Ultrasound in the Generation of Reactive Oxygen Species for Biomedical Applications. In: FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, vol. 7. ISSN 2296-4185
Contributo su Rivista - Cauda, V.; Canavese, G.; Limongi, T.; Garino, N.; Laurenti, M.; Dumontel, B.; Canta, M.; ... (2019)
Biomimetic Non-Immunogenic Nanoassembly for the Antitumor Therapy. N. brevetto: 18807126.0-1109, propr. brevetto: 2 -Autori del brevetto
Brevetti - Garino, Nadia; Limongi, Tania; Dumontel, Bianca; Canta, Marta; Racca, Luisa; Laurenti, ... (2019)
A Microwave-Assisted Synthesis of Zinc Oxide Nanocrystals Finely Tuned for Biological Applications. In: NANOMATERIALS, vol. 9. ISSN 2079-4991
Contributo su Rivista - Dumontel, Bianca; Susa, Francesca; Limongi, Tania; Canta, Marta; Racca, Luisa; Chiodoni, ... (2019)
ZnO nanocrystals shuttled by extracellular vesicles as effective Trojan nano-horses against cancer cells. In: NANOMEDICINE. ISSN 1743-5889
Contributo su Rivista - Limongi, Tania; Canta, Marta; Racca, Luisa; Ancona, Andrea; Tritta, Stefania; Vighetto, ... (2019)
Improving dispersal of therapeutic nanoparticles in the human body. In: NANOMEDICINE, vol. 14, pp. 797-801. ISSN 1743-5889
Contributo su Rivista - Susa, F.; Dumontel, B.; Canta, M.; Racca, L.; Garino, N.; Limongi, T.; Chiodoni, A.; ... (2018)
Biomimetic hybrid nanoconstructs for cancer therapy. In: Merck and Elsevier Young Chemists Symposium (MEYCS 2018), Rimini (italy), November 19th – 21st, 2018, pp. 191-191. ISBN: 978-88-94952-03-2
Contributo in Atti di Convegno (Proceeding) - Canavese, Giancarlo; Ancona, Andrea; Racca, Luisa; Canta, Marta; Dumontel, Bianca; ... (2018)
Nanoparticle-assisted ultrasound: a special focus on sonodynamic therapy against cancer. In: CHEMICAL ENGINEERING JOURNAL, vol. 340, pp. 155-172. ISSN 1385-8947
Contributo su Rivista - Dumontel, B.; Canta, M.; Susa, F.; Racca, L.; Ancona, A.; Garino, N.; Limongi, T.; ... (2018)
Enhanced biostability and biocompatibility of zinc oxide nanocrystals shielded by a phospholipid bilayer. In: Merck and Elsevier Young Chemists Symposium (MEYCS 2018), Rimini (italy), November 19th – 21st, 2018, pp. 169-169. ISBN: 978-88-94952-03-2
Contributo in Atti di Convegno (Proceeding) - Ancona, A.; Engelke, H.; Garino, N.; Racca, L.; Dumontel, B.; Fazzini, W.; Cauda, V. (2017)
Lipid-coated zinc oxide nanocrystals as innovative ROS-generators for photodynamic therapy. In: Merck Young Chemists Symposium, Milano Marittima, 13-15 novembre 2017, pp. 50-50. ISBN: 978-88-86208-89-5
Contributo in Atti di Convegno (Proceeding) - Dumontel, B.; Canta, M.; Engelke, H.; Chiodoni, A.; Racca, L.; Ancona, A.; Limongi, T.; ... (2017)
Enhanced Biostability and Cellular Uptake of Zinc Oxide Nanocrystals Shielded with Phospholipid Bilayer. In: JOURNAL OF MATERIALS CHEMISTRY. B, vol. 5, pp. 8799-8813. ISSN 2050-750X
Contributo su Rivista - Racca, Luisa; Dumontel, Bianca; Miccoli, Beatrice; Canta, Marta; Serpe, Loredana; ... (2016)
Investigation of cytotoxic effects of different ZnO nanostructures on living cancer cells. In: Merck Young Chemists Symposium (MYCS 2016), Rimini, 25-27 novembre 2016, pp. 158-158. ISBN: 978-88-86208-92-5
Contributo in Atti di Convegno (Proceeding) - Canta, Marta; Dumontel, Bianca; Racca, Luisa; Chiodoni, Angelica; Cauda, VALENTINA ALICE (2016)
Towards a comprehension of Zinc oxide nanoparticles behavior in inorganic and biological fluids. In: Merck Young Chemists Symposium (MYCS 2016), Rimini, 25-27 novembre 2016, pp. 118-118. ISBN: 978-88-86208-92-5
Contributo in Atti di Convegno (Proceeding)
Società e imprese
Brevetti e altre proprietà intellettuali
- Composizione farmacologica per massimizzare l'efficacia terapeutica degli inibitori del proteasoma.. Brevetto nazionale e internazionale
Inventori: Valentina Alice Cauda - Nanocostrutto di ossido metallico responsivo agli ultrasuoni per teranostica antitumorale. Brevetto nazionale e internazionale
Inventori: Giancarlo Canavese Valentina Alice Cauda Giancarlo Cicero Bianca Dumontel - Nanocostrutto biomimetico non immunogenico ad attivazione remota e controllata per la terapia antitumorale. Brevetto nazionale e internazionale
Inventori: Giancarlo Canavese Valentina Alice Cauda Bianca Dumontel