Ven
17
Mag
Seminari e Convegni
Morphological characterization and modeling of filamentous fungi
The seminar titled "Morphological characterization and modeling of filamentous fungi" will feature the presence of professor Heiko Briesen, holder of the Chair of Process Systems Engineering at the Technical University of Munich, to address the topic of filamentous fungi, which are crucial for producing biotechnological compounds such as antibiotics, enzymes, and organic acids.
Abstract
Antibiotics, enzymes, or organic acids: filamentous fungi are widely used for the production of biotechnological compounds. Hereby, productivity is strongly affected by the fungal morphology formed during submerged cultivations. Fungal pellets, dense agglomerates of branched fibers (hyphae), are often preferred over dispersed mycelia morphology. However, the dense fiber-network of fungal pellets limits the diffusivity of oxygen and substrates into them. To correlate the productivity of a desired compound with pellet morphology, the relatively unexplored three-dimensional (3D) morphology and the diffusive mass transport through this network must be understood. By employing X-ray microcomputed tomography (µCT) measurements of fungal pellets and subsequent 3D image analysis, it becomes possible to locate and quantify hyphal material, tips, and branches of whole fungal pellets. Based on the processed 3D images of fungal pellets, models can be developed to predict growth, metabolism, as well as nutrient and product transport through the mycelial network. Eventually, such single pellet models can be extended to incorporate pellet heterogeneity using population balances to simulate fungal bioprocesses on a technical batch scale.
Speaker: professor Heiko Briesen - Technical University of Munich (Germany)
Biography
Heiko Briensen studied chemical engineering at the University of Karlsruhe and the University of Cincinnati from 1992 to 1997. He went on to earn his doctorate at the Chair of Process Systems Engineering at RWTH Aachen, receiving his doctoral degree in 2002 and his post-doctoral teaching qualification in 2008. Between 2007 and 2008, Briesen headed the Population Dynamics junior research group at the Max Planck Institute for Dynamics of Complex Technical Systems in Magdeburg. He has been a full professor at TUM since November 2008.
Heiko Briesen’s research involves the transfer and new development of process systems engineering concepts for food and beverage technology and biological processes. Insight derived from models combining mathematical and computer science techniques with the latest process expertise serves to develop new and optimize existing products and processes.
For more information contatc the professor Daniele Marchisio at the following e-mail: daniele.marchisio@polito.it
Abstract
Antibiotics, enzymes, or organic acids: filamentous fungi are widely used for the production of biotechnological compounds. Hereby, productivity is strongly affected by the fungal morphology formed during submerged cultivations. Fungal pellets, dense agglomerates of branched fibers (hyphae), are often preferred over dispersed mycelia morphology. However, the dense fiber-network of fungal pellets limits the diffusivity of oxygen and substrates into them. To correlate the productivity of a desired compound with pellet morphology, the relatively unexplored three-dimensional (3D) morphology and the diffusive mass transport through this network must be understood. By employing X-ray microcomputed tomography (µCT) measurements of fungal pellets and subsequent 3D image analysis, it becomes possible to locate and quantify hyphal material, tips, and branches of whole fungal pellets. Based on the processed 3D images of fungal pellets, models can be developed to predict growth, metabolism, as well as nutrient and product transport through the mycelial network. Eventually, such single pellet models can be extended to incorporate pellet heterogeneity using population balances to simulate fungal bioprocesses on a technical batch scale.
Speaker: professor Heiko Briesen - Technical University of Munich (Germany)
Biography
Heiko Briensen studied chemical engineering at the University of Karlsruhe and the University of Cincinnati from 1992 to 1997. He went on to earn his doctorate at the Chair of Process Systems Engineering at RWTH Aachen, receiving his doctoral degree in 2002 and his post-doctoral teaching qualification in 2008. Between 2007 and 2008, Briesen headed the Population Dynamics junior research group at the Max Planck Institute for Dynamics of Complex Technical Systems in Magdeburg. He has been a full professor at TUM since November 2008.
Heiko Briesen’s research involves the transfer and new development of process systems engineering concepts for food and beverage technology and biological processes. Insight derived from models combining mathematical and computer science techniques with the latest process expertise serves to develop new and optimize existing products and processes.
For more information contatc the professor Daniele Marchisio at the following e-mail: daniele.marchisio@polito.it