Ph.D. candidate in Bioingegneria E Scienze Medico-chirurgiche , 39th cycle (2023-2026)
Department of Mechanical and Aerospace Engineering (DIMEAS)
Docente esterno e/o collaboratore didattico
Department of Mechanical and Aerospace Engineering (DIMEAS)
Ospite / Studente in missione
Department of Mechanical and Aerospace Engineering (DIMEAS)
Profile
PhD
Research topic
Design and preclinical validation of targeted drug delivery systems
Tutors
Research interests
Biography
I am currently pursuing my Ph.D. in Bioengineering and Medical-Surgical Sciences within the Department of Mechanical and Aerospace Engineering (DIMEAS) of Politecnico di Torino. The main focus of my PhD is the development of new technologies for RNA-based therapies to counteract age-related diseases, particularly cardiac diseases, by accurate design of new effective and simple drug delivery approaches.
My academic journey commenced with a Bachelor's Degree in Chemical and Food Engineering (June 2020). Subsequently, I furthered my education by completing a Master's Degree in Biomedical Engineering (December 2022), both accomplished at Politecnico di Torino. I performed my Master's thesis project, as a part of our commitment within the European Research Council (ERC) BIORECAR project, entitled "Surface functionalization of bioartificial nanoparticles for selective targeting in cardiac cell reprogramming". During my thesis, I had the opportunity to prepare nanoparticles as carriers for direct reprogramming in the field of cardiac regeneration. From March 2023 I am a Post-graduate Fellow at Politecnico di Torino. This position allowed me to improve my research experience and to work on the new European Research Council (ERC) POLIRNA project, aimed at the development of hybrid nanoparticles embedding miRNA and functionalized with specific ligands.
My academic journey commenced with a Bachelor's Degree in Chemical and Food Engineering (June 2020). Subsequently, I furthered my education by completing a Master's Degree in Biomedical Engineering (December 2022), both accomplished at Politecnico di Torino. I performed my Master's thesis project, as a part of our commitment within the European Research Council (ERC) BIORECAR project, entitled "Surface functionalization of bioartificial nanoparticles for selective targeting in cardiac cell reprogramming". During my thesis, I had the opportunity to prepare nanoparticles as carriers for direct reprogramming in the field of cardiac regeneration. From March 2023 I am a Post-graduate Fellow at Politecnico di Torino. This position allowed me to improve my research experience and to work on the new European Research Council (ERC) POLIRNA project, aimed at the development of hybrid nanoparticles embedding miRNA and functionalized with specific ligands.
Skills
Open badges
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COMUNICARE LA RICERCA ALLA CITTADINANZA
Issued by Politecnico di Torino on 01-07-2025
Awards and Honors
- MPS Best Poster Presentation Award, for the presentation “Innovative hybrid polymer-lipid nanoparticles for targeted microRNAs-based cardiac regeneration”, received at the 34th Annual Conference of the European Society for Biomaterials (ESB), Torino, Italy, September 7-11, 2025. (2025)
- Travel awards for participation in the 2024 Summer Immersion on Innovative Approaches in Science in Washington DC (USA). (2024)
Teaching
Teachings
Master of Science
- Ingegneria per la medicina rigenerativa/Bioreattori (modulo di Ingegneria per la medicina rigenerativa). A.A. 2025/26, INGEGNERIA BIOMEDICA. Collaboratore del corso
- Laboratory of Tissues and Physiological Processes' Models. A.A. 2024/25, INGEGNERIA BIOMEDICA. Collaboratore del corso
Publications
PoliTO co-authors
Latest publications View all publications in Porto@Iris
- Stola, Giovanni Paolo; Nicoletti, Letizia; Coletto, Martina; De Carolis, Martina; ... (2025)
Development of Functionalized Polymer-Lipid Hybrid Nanoparticles for Skeletal Muscle-Targeted RNA Delivery in Spinal and Bulbar Muscular Atrophy (SBMA) Therapy. In: TISSUE ENGINEERING. PART A, pp. 21-22. ISSN 1937-335X
Contributo su Rivista - Nicoletti, L.; Coletto, M.; Stola, G. P.; Paoletti, C.; Marcello, E.; Testore, D.; ... (2025)
Strategies for the delivery of RNA therapeutics to diseased heart tissue. In: EXPERT OPINION ON DRUG DELIVERY, vol. 22, pp. 1583-1598. ISSN 1744-7593
Contributo su Rivista - Marcello, Elena; Tivano, Francesca; Stola, Giovanni Paolo; Nicoletti, Letizia; Paoletti, ... (2025)
Design and validation of a hydrogel-based advanced delivery system for cardiac regeneration after myocardial infarction. In: Next Gen3Ration Research, Genova, 18-19 Settembre 2025
Contributo in Atti di Convegno (Proceeding) - Coletto, Martina; Paoletti, Camilla; Nicoletti, Letizia; Stola, Giovanni Paolo; Mattu, ... (2025)
Innovative hybrid polymer-lipid nanoparticles for targeted microRNAs-based cardiac regeneration. In: 34TH ANNUAL CONFERENCE OF THE EUROPEAN SOCIETY FOR BIOMATERIALS, Torino (IT), September 7-11, 2025
Contributo in Atti di Convegno (Proceeding) - Coletto, Martina; Nicoletti, Letizia; Paoletti, Camilla; Marcello, Elena; Stola, ... (2025)
Hybrid polymer-lipid nanoparticles as innovative transfection vectors for microRNA delivery. In: Controlled Release Society (CRS) 2025 Annual Meeting and Exposition, Philadelphia (USA), July 14-18, 2025
Contributo in Atti di Convegno (Proceeding)