Ph.D. in Bioingegneria E Scienze Medico-chirurgiche , 36th cycle (2020-2023)
Ph.D. obtained in 2024
Dissertation:
Design of injectable hydrogels and nanogels relying on Schiff-base crosslinking of custom-made poly(ether urethane)s and photo-cured methacryloyl gelatin for in situ drug delivery and biological tissue mimics (Abstract)
Tutors:
Gianluca Ciardelli Valeria Chiono Monica BoffitoProfile
Research topic
Design of injectable hydrogels as platform for in situ drug delivery and tissue engineering
Research interests
Biography
Roberta Pappalardo received her Bachelor's degree in Biomedical Engineering from Politecnico di Torino in March 2017. In July 2019, she obtained cum laude the Master’s degree in Biomedical Engineering (Bionanotechnology field) with a thesis entitled "Design of stimuli responsive polyurethane-based hydrogels for 3D printing application” (under the supervison of Prof. Gianluca Ciardelli, Prof. Valeria Chiono, Prof. Monica Boffito). The thesis work aimed on poly(ether urethane) development as smart polymeric materials able to respond to three different stimuli (i.e., temperature, pH and UV-Vis light) and suitable as bioinks for the fabrication of three-dimensional scaffolds for tissue engineering and regenerative medicine applications. Part of these activities produced a research paper in international peer-review journal. From February to October 2020, she worked as research fellow in the Bioengineering Group at Politecnico di Torino under the supervision of Prof. Gianluca Ciardelli focusing on the design of gelatin methacryloyl-based bioinks for 3D bioprinting. From November 2020 Roberta is Ph.D. student in Bioengineering and Medical-Surgical Sciences at Politecnico di Torino and Università degli Studi di Torino under the supervision of Prof. Gianluca Ciardelli, Prof. Valeria Chiono, Prof. Monica Boffito. Her reasearch activity mainly concern the design of injectable hydrogels based on Schiff-base linkages as a promising platform for in situ drug delivery and tissue engineering. During her Ph.D. she has been involved in the European H2020 Project “Development of Extracellular Vesicles loaded hydrogel coatings with immunomodulatory activity for promoted regenerative osseointegration of revision endoprosthesis (EVPRO)” working on the preparation of bioactive gelatin-based bioinks for the design of osteoblast/osteoclast co-culture 3D model.
Teaching
Teachings
Master of Science
- Ingegneria per la medicina rigenerativa. A.A. 2021/22, INGEGNERIA BIOMEDICA. Collaboratore del corso
- Ingegneria per la medicina rigenerativa/Bioreattori (modulo di Ingegneria per la medicina rigenerativa). A.A. 2022/23, INGEGNERIA BIOMEDICA. Collaboratore del corso
- Ingegneria per la medicina rigenerativa/Bioreattori (modulo di Ingegneria per la medicina rigenerativa). A.A. 2023/24, INGEGNERIA BIOMEDICA. Collaboratore del corso
Publications
Works published during the Ph.D. View all publications in Porto@Iris
- Pappalardo, Roberta (2024)
Design of injectable hydrogels and nanogels relying on Schiff-base crosslinking of custom-made poly(ether urethane)s and photo-cured methacryloyl gelatin for in situ drug delivery and biological tissue mimics. relatore: CIARDELLI, GIANLUCA; CHIONO, VALERIA; , 36. XXXVI Ciclo, P.: 353
Doctoral Thesis - Laurano, Rossella; Boffito, Monica; Cassino, Claudio; Midei, Ludovica; Pappalardo, ... (2023)
Thiol-Ene Photo-Click Hydrogels with Tunable Mechanical Properties Resulting from the Exposure of Different -Ene Moieties through a Green Chemistry. In: MATERIALS, vol. 16. ISSN 1996-1944
Contributo su Rivista - Laurano, Rossella; Boffito, Monica; Pappalardo, Roberta; Chiono, Valeria; Ciardelli, ... (2022)
3D printed bone tissue-mimicking constructs as in vitro preclinical testing platform. In: International conference on biofabrication 2022, Montecatini Terme, Italia, 25-28 Settembre 2022
Contributo in Atti di Convegno (Proceeding) - Laurano, Rossella; Boffito, Monica; Zoso, Alice; Pappalardo, Roberta; Chiono, Valeria; ... (2021)
3D printed GelMA/Hydroxyapatite scaffolds for engineering bone-like tissue: a powerful tool to preclinically validate new prosthetic devices. In: 6th World TERMIS Conference 2021, online, 15-19 Novembre 2021
Contributo in Atti di Convegno (Proceeding)