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TOSCA (Total Operation Management for Safety Critical Activities) is concerned with the integration of industrial operations into a total performance management system so that concerns about safety, quality and productivity are addressed in an integrated way during life-cycle of a project or a product. The industrial domain of application regards process control industries (e.g., chemical industries, power generation, offshore oil & gas platforms, etc.) that may vary in size, regulatory and cultural aspects. TOSCA will examine vulnerabilities of the technical, human and organisational systems that may have an impact insafety, quality and productivity.