Davide Fissore

Full Professor
Department of Applied Science and Technology (DISAT)

  • Coordinatore Collegio di Ingegneria Chimica e dei Materiali
  • Member Commissione istruttoria per il Coordinamento dell'Attività Didattica e formativa
  • Member of Interdepartmental Center R3C - Responsible Risk Resilience Centre

Profile

Research interests

freeze drying
image analysis
nanoparticles
near infrared spectroscopy
process control
process monitoring
statistical process control
thermography (imaging)

Research topics

  • Drug delivery systems based on nanoparticles: the research activity is focused on the optimization of the reactor configuration and of the operating parameters, aiming at maximizing the loading of the desired component, as well as maintaining particles dimension in the desired range. Release of the active ingredient is also investigated.
  • Freeze-drying: Monitoring, control, infrared thermography, Quality by design, The research is focused on the optimization, monitoring and control of the batch freeze-drying of pharmaceuticals, where original and effective solutions for both the primary and the secondary drying stages were proposed, validated and, in some cases, patented. The application of these methodologies to food freeze-drying was also investigated.

Skills

ERC sectors

PE8_2 - Chemical engineering, technical chemistry
PE8_4 - Computational engineering
PE8_13 - Industrial bioengineering
PE8_9 - Production technology, process engineering

Editorial boards

  • PHARMACEUTICS (2021-), Guest Editor of magazine or editorial series
  • JOURNAL OF PHARMACEUTICAL SCIENCES (2019-2023), Other editorial activities

Teaching

PhD Boards

  • INGEGNERIA CHIMICA, 2021/2022 (38. ciclo)
    Politecnico di TORINO
  • INGEGNERIA CHIMICA, 2020/2021 (37. ciclo)
    Politecnico di TORINO
  • INGEGNERIA CHIMICA, 2019/2020 (36. ciclo)
    Politecnico di TORINO
  • INGEGNERIA CHIMICA, 2018/2019 (35. ciclo)
    Politecnico di TORINO
  • INGEGNERIA CHIMICA, 2017/2018 (34. ciclo)
    Politecnico di TORINO
  • INGEGNERIA CHIMICA, 2016/2017 (33. ciclo)
    Politecnico di TORINO
  • INGEGNERIA CHIMICA, 2015/2016 (32. ciclo)
    Politecnico di TORINO
  • INGEGNERIA CHIMICA, 2014/2015 (31. ciclo)
    Politecnico di TORINO
  • INGEGNERIA CHIMICA, 2013/2014 (30. ciclo)
    Politecnico di TORINO
  • INGEGNERIA CHIMICA, 2012/2013 (29. ciclo)
    Politecnico di TORINO
  • INGEGNERIA CHIMICA, 2011/2012 (28. ciclo)
    Politecnico di TORINO
  • INGEGNERIA CHIMICA, 2010/2011 (27. ciclo)
    Politecnico di TORINO
  • INGEGNERIA CHIMICA, 2009/2010 (26. ciclo)
    Politecnico di TORINO
  • INGEGNERIA CHIMICA, 2008/2009 (25. ciclo)
    Politecnico di TORINO
MostraNascondi collegi passati

Courses of Study Boards

Teachings

PhD

MostraNascondi A.A. passati

Master of Science

MostraNascondi A.A. passati

Bachelor of Science

MostraNascondi A.A. passati

Teaching and training projects

Projects funded by commercial contracts

  • Quality-by-Design in the manufacturing of pharmaceutical products, (2019-2019) - Responsabile Scientifico
    Commercial contracts

Research

Institute

Research groups/teams

Laboratories

Research projects

Projects funded by competitive calls

  • ProPep: Sviluppo di strumenti innovativi per la protezione del peperone piemontese dall'avvizzimento maculato causato da virosi, (2018-2021) - Responsabile Scientifico
    Corporate-funded and donor-funded research

Projects funded by commercial contracts

  • Convenzione dipartimentale tra il Politecnico di Torino e Benefit Mazzini Lab s.r.l., (2022-2025) - Responsabile Scientifico
    Departmental agreements
  • Convenzione dipartimentale tra Politecnico di Torino - Dipartimento di scienza applicata e Tecnologia (DISAT) e Archivio di Stato di Torino, (2022-2025) - Responsabile Scientifico
    Departmental agreements
  • Experimental project on the use of small-scale freeze-dryers for the design and optimization of freeze-drying processes in vials, (2020-2023) - Responsabile Scientifico
    Memoranda of Understanding
  • Analisi dei rischi lungo la supply chain per l’industria alimentare, (2021-2022) - Responsabile Scientifico
    Commercial Research
  • Investigation of the performance of a micro freeze-dryer, (2018-2019) - Responsabile Scientifico
    Commercial Research
  • PRODUZIONE DI ENERGIA MEDIANTE GASSIFICAZIONE DI BIOMASSE E ASSIMILABILI, (2013-2013) - Responsabile Scientifico
    Consulting
  • GASSIFICAZIONE DI BIOMASSE E ASSIMILABILI , (2013-2013) - Responsabile Scientifico
    Consulting
  • SVILUPPO DI UN PROCESSO DI PIROLIZZAZIONE DI RIFIUTI INDUSTRIALI E DOMESTICI 1A FASE, (2010-2012) - Responsabile Scientifico
    Commercial Research
  • ANNULLATO SVILUPPO DI UN PROCESSO DI PIROLIZZAZIONE DI RIFIUTI INDUSTRIALI E DOMESTICI 2A FASE VEDI 965-2010 ANNULLATO, (2010-2012) - Responsabile Scientifico
    Commercial Research
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Supervised PhD students

Other activities and projects related to research

The research activity of Davide Fissore is mainly focused on process modelling and on the design and validation of advanced model-based tools for process monitoring and control.

His early research interests focused on the catalytic treatment of lean VOC-air mixtures in thermally and catalytically stabilised combustors, and in forced unsteady-state reactors.

Later, he investigated the possibility of using unsteady-state reactors for synthesis reactions (e.g. syngas production) and for chromatographic process (e.g. the catalytic reduction of NOx with ammonia). He developed, and validated, both first-principles and black-box models for process control and optimisation, and he proposed advanced monitoring (soft-sensors) and control (Model Predictive Control, Robust Control) systems for these processes.

After getting the PhD degree, the research activity was still focused on the monitoring and control of chemical processes with complex dynamics, and then moved to a different field, i.e. pharmaceutical engineering and, in particular, in applying the "Quality by Design" concept in the field of pharmaceuticals manufacturing. The research was focused on the optimization, monitoring and control of the batch freeze-drying of pharmaceuticals, where he proposed, validated, and, in some cases, patented, original and effective solutions for both the primary and the secondary drying stages.

The application of these methodologies to food freeze-drying was also investigated.

A recent research field is the synthesis and preservation (using freeze-drying) of polymeric nanoparticles for drug delivery and for food fortification. In this framework the research activity has been focused on the optimization of the reactor configuration and of the operating parameters, aiming at maximizing the loading of the desired component, as well as maintaining particles dimension in the desired range. Release of the active ingredient has also been investigated.

Publications

Latest publications View all publications in Porto@Iris

Society and Enterprise

Patents and other intellectual properties

  • Pirolizzatore continuo polivalente. national Patent - Responsabile Scientifico
    Commercial Research
  • Eliminazione del TAR e gassificazione del residuo carbonioso provenienti da pirolisi di sostanze organiche. national Patent - Responsabile Scientifico
    Commercial Research