Freeze Drying of Therapeutic Proteins: A Simulation Approach to Optimize Formulation and Process

• Introductory Certificate in Project Management (2018)
• L'articolo "Application of the Quality by Design approach to the freezing step of freeze-drying: building the design space" è selezionato come 'featured article' dagli editori della rivista perchè ritenuto originale e significativo da un punto di vista scientifico. (2018)
• Legacy BioDesign LLC seleziona l'articolo 'Water Entrapment and Structure Ordering as Protection Mechanisms for Protein Structural Preservation' come particolarmente rilevante per gli esperti di formulazione e sviluppo di processo, e ne include una breve descrizione nella rivista 'Staying Current: Formulation of Biopharmaceuticals' (2018)
• Advances in Engineering seleziona l'articolo 'Clarifying the role of cryo- and lyo-protectants in the biopreservation of proteins' per il suo originale contenuto scientifico, e decide di dedicarvi un breve contributo. (2018)
• premio miglior poster alla protein stability conference 2019 in Colorado (2019)

Bachelor of Science

• Controllo, strumentazione e sicurezza per i processi chimici (modulo di Controllo e strumentazione per i processi chimici). A.A. 2018/19, INGEGNERIA CHIMICA E ALIMENTARE. Collaboratore del corso

• Arsiccio, A.; Mccarty, J.; Pisano, R.; Shea, J. -E. (2020)
  Heightened cold-denaturation of proteins at the ice-water interface. In: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 142, pp. 5722-5730. ISSN 0002-7863
  Contributo su Rivista
• Arsiccio, A.; Ganguly, P.; La Cortiglia, L.; Shea, J. -E.; Pisano, R. (2020)
  ADD force field for sugars and polyols: predicting the additivity of protein-osmolyte interaction. In: JOURNAL OF PHYSICAL CHEMISTRY. B, CONDENSED MATTER, MATERIALS, SURFACES, INTERFACES & BIOPHYSICAL, vol. 124, pp. 7779-7790. ISSN 1520-6106
  Contributo su Rivista
• Arsiccio, A.; Giorsello, P.; Marenco, L.; Pisano, R. (2020)
  Considerations on protein stability during freezing and its impact on the freeze-drying cycle: a design space approach. In: JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 109, pp. 464-475. ISSN 0022-3549
  Contributo su Rivista
• Oddone, I.; Arsiccio, A.; Duru, C.; Malik, K.; Ferguson, J.; Pisano, R.; Matejtschuk, P. (2020)
  Vacuum-induced surface freezing for the freeze-drying of the Human Growth Hormone: how does nucleation control affect protein stability?. In: JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 109, pp. 254-263. ISSN 0022-3549
  Contributo su Rivista
• Arsiccio, Andrea (2020)
  Freeze Drying of Therapeutic Proteins: A Simulation Approach to Optimize Formulation and Process Conditions. relatore: PISANO, ROBERTO; BARRESI, Antonello; , 32. XXXII Ciclo, P.: 286
  Doctoral Thesis
• Arsiccio, A.; Matejtschuk, P.; Ezeajughi, E.; Riches-Duit, A.; Bullen, A.; Malik, K.; ... (2020)
  Impact of controlled vacuum induced surface freezing on the freeze drying of human plasma. In: INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 582. ISSN 0378-5173
  Contributo su Rivista
• Arsiccio, A.; Pisano, R. (2020)
  The ice-water interface and protein stability: a review. In: JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 109, pp. 2116-2130. ISSN 0022-3549
  Contributo su Rivista
• Arsiccio, A.; Marenco, L.; Pisano, R. (2020)
  A model-based approach for the rational design of the freeze-thawing of a protein-based formulation. In: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, vol. 25, pp. 823-831. ISSN 1083-7450
  Contributo su Rivista
• Arsiccio, Andrea; Pisano, Roberto (2019)
  Rational design of freeze-drying formulations: a molecular dynamics approach. In: 7th European Conference “EuroDrying’2019”, Torino, July 10-12, 2019
  Contributo in Atti di Convegno (Proceeding)
• Arsiccio, Andrea; Mccarty, James; Shea, Joan-Emma; Pisano, Roberto (2019)
  Effect of Surfactants on Surface-Induced Denaturation of Proteins: An Insight from Molecular Dynamics. In: 2019 Colorado Protein Stability Conference - 25th Anniversary, Breckenridge, Colorado, USA, July 29 - August 1
  Contributo in Atti di Convegno (Proceeding)
• Arsiccio, A.; Metcalfe, C.; Riches, A.; Pisano, R.; Raut, S.; Coxon, C. (2019)
  A proximity-based in silico approach to identify redox-labile disulfide bonds: the example of FVIII. In: ISTH 2019 Congress, Melbourne, Australia, July 6-10
  Contributo in Atti di Convegno (Proceeding)
• Arsiccio, Andrea; Pisano, Roberto (2019)
  Rational design of freeze-drying formulations: A Molecular Dynamics approach. In: 9th International Symposium on Lyophilization of Pharmaceuticals, Ghent, September 2-6, 2019, pp. 55-56
  Contributo in Atti di Convegno (Proceeding)
• Pisano, R.; Arsiccio, A.; Capozzi, L. C.; Trout, B. L. (2019)
  Achieving continuous manufacturing in lyophilization: technologies and approaches. In: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 142, pp. 265-279. ISSN 0939-6411
  Contributo su Rivista
• Arsiccio, Andrea; Mccarty, James; Shea, Joan-Emma; Pisano, Roberto (2019)
  Surface-driven denaturation of proteins during freeze-drying: An insight into the role of surfactants. In: 9th International Symposium on Lyophilization of Pharmaceuticals, Ghent, September 2-6, 2019, pp. 41-42
  Contributo in Atti di Convegno (Proceeding)
• Pisano, Roberto; Arsiccio, Andrea (2019)
  Formulation design and optimization using molecular dynamics. In: Freeze-Drying of Pharmaceutical Products / Fissore D., Pisano R., Barresi A. A., Boca Raton (Florida), USA, CRC Press, pp. 11-31. ISBN: 978-0367076801
  Contributo in Volume
• Arsiccio, Andrea; Paladini, Andrea; Pattarino, Franco; Pisano, Roberto (2019)
  Designing the optimal formulation for biopharmaceuticals: a new approach combining molecular dynamics and experiments. In: JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 108, pp. 431-438. ISSN 0022-3549
  Contributo su Rivista
• Pisano, R.; Arsiccio, A.; Nakagawa, K.; Barresi, A. A. (2019)
  Tuning, measurement and prediction of the impact of freezing on product morphology: A step toward improved design of freeze-drying cycles. In: DRYING TECHNOLOGY, vol. 37, pp. 579-599. ISSN 0737-3937
  Contributo su Rivista
• Arsiccio, Andrea; Pisano, Roberto (2019)
  A design space approach for the freezing step of freeze-drying: considerations for process performance and protein stability. In: 7th European Conference “EuroDrying’2019”, Torino, July 10-12, 2019
  Contributo in Atti di Convegno (Proceeding)
• Arsiccio, A.; Sparavigna, A. C.; Pisano, R.; Barresi, A. A. (2019)
  Measuring and predicting pore size distribution of freeze-dried solutions. In: DRYING TECHNOLOGY, vol. 37, pp. 435-447. ISSN 0737-3937
  Contributo su Rivista
• Arsiccio, A.; Sparavigna, A. C.; Barresi, A. A. (2019)
  Image segmentation applied to the investigation of craquelure domains in paintings. In: 7th European Drying Conference, Torino, 10-12 July 2019, pp. 547-554
  Contributo in Atti di Convegno (Proceeding)