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GLYCOVIEW - EIT Health - Glycoview
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Abstract
GlycoView is an innovative endogenous MRI method for the in vivo diagnosis of both tumor and neurodegenerative pathologies (Alzheimer's, Parkinson's, ALS) based on the localized observation of the eregulation of glycolysis. The method responds to an extremely relevant clinical need as it has an endogenous character, i.e. it does not involve the use of contrast agents. It is non-invasive and compatible with fragile patients (e.g. with renal failure). It also allows a quantification of the kinetics of deregulated metabolic processes for a better characterization of pathologies (e.g. tumor aggressiveness). Glycoview is based a radical innovation in the 31P CEST paradigm, allowing the amplification by 4 orders of magnitude of endogenous signals of phosphorylated substrates that are otherwise below detection thresholds. Glycoview will develop and commercialize a suite of software tools for image acquisition, data reconstruction, and metabolic analysis compatible with existing MRI devices.
Structures
Partners
- POLITECNICO DI TORINO - AMMINISTRAZIONE CENTRALE
- UNIVERSITA' DEGLI STUDI DI TORINO - Coordinator
Keywords
ERC sectors
Sustainable Development Goals
Budget
| Total cost: | € 74,000.00 |
|---|---|
| Total contribution: | € 50,000.00 |
| PoliTo total cost: | € 21,000.00 |
| PoliTo contribution: | € 16,000.00 |