Angela Re

• Activities can be summarized in: A. Development of modelling techniques for the study of post-transcriptional regulation of gene expression mediated by specific classes of proteins. B. Statistical inferential techniques for the identification of mitochondrial translation-blocking molecules with high therapeutic potential in particular cancers, notably glioblastoma. C. Formal methods oriented towards the identification of DNA alterations involved in tumour genesis. D. Analysis of biological sequences to identify signal peptides involved in unconventional termination of protein translation, which have been used to characterise the degradation mechanism of polypeptides destined to reach the endoplasmic reticulum. E. Development of methods for the coordinated representation, organisation and integrated analysis of multilevel and highly processive experimental data, including the development of new approaches for the identification of modular structures and the differential analysis of biological networks. F. Meta-analysis of gene expression data (transcriptional, translational) to study post-transcriptional control in the determination of protein abundance. The application of different statistical approaches led to the development of a model of substantial decoupling between variation in transcript abundance and variation in the level of loading in the translational apparatus. G. Development of a scientific database for regulatory elements acting at the post-transcriptional level which gained ample acknowledgments by the scientific community. H. Integrated analysis of multi-level gene expression data (genome-wide DNA copy number profiles and transcriptomic profiles) for the identification of deregulated interaction networks in specific tumour forms.
• Le attività di ricerca si sviluppano lungo due linee principali qui introdotte: A. Rappresentazioni guidate dai dati dello spazio biomolecolare attraverso lo sviluppo di banche dati, strumenti di annotazione e predizione. B. Microbiologia computazionale applicata a organismi procariotici e ecosistemi declinata in diversi contesti applicativi.

Settori ERC

SDG

• Socio effettivo o corrispondente - European Society of Applied Biocatalysis (ESAB), Belgio (2023-2025)

• MSYSTEMS (2023-2026), Membro del Comitato Editoriale

• Collegio di Ingegneria Gestionale e della Produzione. Componente

Dottorato di ricerca

• Biotecnologie per la sostenibilità nella produzione chimica. A.A. 2024/25, MATERIALI, PROCESSI SOSTENIBILI E SISTEMI PER LA TRANSIZIONE ENERGETICA. Titolare del corso

Corso di laurea di 1° livello

• Fondamenti di fisica. A.A. 2024/25, TECNOLOGIE PER L'INDUSTRIA MANIFATTURIERA. Titolare del corso
• Fondamenti di fisica. A.A. 2023/24, TECNOLOGIE PER L'INDUSTRIA MANIFATTURIERA. Titolare del corso
• Fondamenti di fisica. A.A. 2022/23, TECNOLOGIE PER L'INDUSTRIA MANIFATTURIERA. Titolare del corso

- Dottorato di ricerca

Biotecnologie per la sostenibilità nella produzione chimica. A.A. 2024/25, MATERIALI, PROCESSI SOSTENIBILI E SISTEMI PER LA TRANSIZIONE ENERGETICA.

- Corso di laurea di 1° livello

Fondamenti di fisica. A.A. 2024/25, TECNOLOGIE PER L'INDUSTRIA MANIFATTURIERA.

• Istituto Fundamental Physics and Materials for Nanotechnology (DISAT)

Progetti finanziati da bandi competitivi

• PROT-mBIOMA-AD - A computational pipeline for the analysis of the role of proteins from unknown species in shotgun metagenomics data: application to the study of gut microbiota in a mouse model of Alzheimer's disease., (2023-2025) - Responsabile Scientifico
  PNRR – Missione 4
• NEST - Spoke 3 - NEST - Network 4 Energy Sustainable Transition - Spoke 3, (2022-2025) - Componente gruppo di Ricerca
  PNRR – Missione 4

Progetti finanziati da contratti commerciali

• Contratto di ricerca (TECHNICAL SERVICES AGREEMENT) tra il Politecnico (DISAT) e Solvay Specialty Polymers Italy S.p.A. per la realizzazione del Progetto di Ricerca “Development of PVDF-based polymeric membranes applied as a solid-state electrolyte separator in the lithium battery sector” , (periodo sconosciuto) - Componente gruppo di Ricerca
  Ricerca Commerciale

• Giulia Usai. Corso in Ingegneria Chimica (36^o ciclo, 2020-2024)
  Tesi: Green Chemicals via Photosynthetic Microbial Factories: Integrating Metabolic and Bioprocess Engineering for 2-Phenylethanol Production and CO2 Valorization
• Luca Ricci. Corso in Ingegneria Chimica (35^o ciclo, 2019-2023)
  Tesi: Microbial valorization of C1 waste gases for 2,3-butanediol production: a single and a double stage approach

• Ricci, Luca; Cen, Xuecong; Zu, Yuexuan; Antonicelli, Giacomo; Chen, Zhen; Fino, Debora; ... (2025)
  Metabolic Engineering of E. coli for Enhanced Diols Production from Acetate. In: ACS SYNTHETIC BIOLOGY, vol. 14, pp. 1204-1219. ISSN 2161-5063
  Contributo su Rivista
• Cocchi, Simona; Greco, Valentina; Sidarovich, Viktoryia; Vigna, Jacopo; Broso, ... (2024)
  EGCG Disrupts the LIN28B/Let-7 Interaction and Reduces Neuroblastoma Aggressiveness. In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 25, pp. 1-21. ISSN 1422-0067
  Contributo su Rivista
• Usai, G; Cordara, A; Mazzocchi, E; Re, Angela; Fino, D; Pirri, Cf; Menin, B (2024)
  Coupling dairy wastewaters for nutritional balancing and water recycling: sustainable heterologous 2-phenylethanol production by engineered cyanobacteria. In: FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, vol. 12, pp. 01-18. ISSN 2296-4185
  Contributo su Rivista
• Politano, Gianfranco; Benso, Alfredo; Rehman, Hafeez Ur; Re, Angela (2024)
  PRONTO-TK: a user-friendly PROtein Neural neTwOrk tool-kit for accessible protein function prediction. In: NAR GENOMICS AND BIOINFORMATICS, vol. 6. ISSN 2631-9268
  Contributo su Rivista
• Favero, Francesco; Re, Angela; Dason, Mohammed Salim; Gravina, Teresa; Gagliardi, Maria; ... (2024)
  Characterization of gut microbiota dynamics in an Alzheimer’s disease mouse model through clade-specific marker-based analysis of shotgun metagenomic data. In: BIOLOGY DIRECT, vol. 19, pp. 1-16. ISSN 1745-6150
  Contributo su Rivista