Andrea Bezze

PhD Student in Bioingegneria E Scienze Medico-chirurgiche , 38th cycle (2022-2025)
Department of Mechanical and Aerospace Engineering (DIMEAS)

Docente esterno e/o collaboratore didattico
Department of Mechanical and Aerospace Engineering (DIMEAS)

Profile

PhD

Research topic

Design of in vitro models for the validation of nanoparticles- and cell- based drug delivery systems

Tutors

Research interests

Nanomedicine
Bionanotechnology

Biography

Andrea Bezze is a PhD student in Bioengineering and Medical-Surgical Sciences at the Department of Mechanical and Aerospace Engineering (DIMEAS) of Politecnico di Torino. He works in the Materials in bionanotechnology and biomedical lab research group on designing experimental tumour models to evaluate innovative drug delivery mechanisms mediated by nanoparticles and cells.
He graduated from the I.I.S. Fermi-Galilei scientific high school with 100 cum laude in 2016. The same year, he enrolled in the Biomedical Engineering Faculty of the Politecnico di Torino, where he also joined the Young Talents Programme. He got a bachelor’s degree (September 2019) and, later, a master’s degree (December 2021) in Biomedical Engineering - Bionanotechnology specialist pathway at the Politecnico di Torino, both with a final grade of 110 cum laude. He also obtained a Double Degree from the Biomedical Engineering Faculty of the Politecnico di Milano as part of the Alta Scuola Politecnica (ASP) programme.
As part of the ASP programme, he also joined the PNRelay 2.020 Project, which aimed to develop a fully implantable, highly compact neural interface to detect peripheral nerve activity in neuroprosthetics.
He performed a master's thesis in the PolitoBIOMed Lab - Biomedical Engineering Lab under the supervision of Professor Gianluca Ciardelli and Clara Mattu (from the Politecnico di Torino) and Professor Gabriele Candiani (from Politecnico di Milano). His work focused on designing vascularized glioblastoma models and nanomedicines against this tumour.
In January 2022, he got a position as a Post-graduate Fellow under the supervision of Professor Ciardelli and, then, as a PhD student (November 2022) under Professor Mattu.
His work has focused on developing and validating transport systems for small molecules and other chemotherapeutic agents to overcome biological barriers to delivery and increase treatment efficacy against brain tumours.
He is developing a spheroid-based model of glioblastoma capable of replicating the histological complexity of the tumour microenvironment. He is also optimizing the integration of this model with microfluidic platforms that replicate the vascular network of brain capillaries.
He is involved in the synthesis and characterization of nanoparticles for drug delivery. He is studying microglia cell-based transport systems to facilitate the penetration of nanomedicines through the blood-brain barrier and increase accumulation in glioblastoma.
He is co-supervising 2 master’s thesis students in collaboration with the Italian Institute of Genomic Medicine (IIGM) of Torino.

Skills

ERC sectors

PE11_1 - Engineering of biomaterials, biomimetic, bioinspired and bio-enabled materials
PE8_13 - Industrial bioengineering
PE11_9 - Nanomaterials engineering, e.g. nanoparticles, nanoporous materials, 1D & 2D nanomaterials

SDG

Goal 3: Good health and well-being
Goal 9: Industry, Innovation, and Infrastructure

Awards and Honors

  • Award "Premio IPAM-Farmindustria 2023" for the best work on the application of the 3Rs principle in drug development and in the other fields of biomedical sciences. (2024)
  • Award for the best oral presentation at the Research & Nanomedicine Workshop (Seventh Edition) at Pavia (2023)
  • Supporting Grant for the 33rd Annual Conference of the European Society for Biomaterials (ESB 2023), awarded by the Società Italiana Biomateriali (2023)

Teaching

Teachings

Master of Science

Publications

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