Ph.D. candidate in Bioingegneria E Scienze Medico-chirurgiche , 38th cycle (2022-2025)
Department of Mechanical and Aerospace Engineering (DIMEAS)
Docente esterno e/o collaboratore didattico
Department of Mechanical and Aerospace Engineering (DIMEAS)
Profile
PhD
Research topic
Design of in vitro models for the validation of nanoparticles- and cell- based drug delivery systems
Tutors
Research interests
Biography
He graduated from the I.I.S. Fermi-Galilei scientific high school with 100 cum laude in 2016. The same year, he enrolled in the Biomedical Engineering Faculty of the Politecnico di Torino, where he also joined the Young Talents Programme. He got a bachelor’s degree (September 2019) and, later, a master’s degree (December 2021) in Biomedical Engineering - Bionanotechnology specialist pathway at the Politecnico di Torino, both with a final grade of 110 cum laude. He also obtained a Double Degree from the Biomedical Engineering Faculty of the Politecnico di Milano as part of the Alta Scuola Politecnica (ASP) programme.
As part of the ASP programme, he also joined the PNRelay 2.020 Project, which aimed to develop a fully implantable, highly compact neural interface to detect peripheral nerve activity in neuroprosthetics.
He performed a master's thesis in the PolitoBIOMed Lab - Biomedical Engineering Lab under the supervision of Professor Gianluca Ciardelli and Clara Mattu (from the Politecnico di Torino) and Professor Gabriele Candiani (from Politecnico di Milano). His work focused on designing vascularized glioblastoma models and nanomedicines against this tumour.
In January 2022, he got a position as a Post-graduate Fellow under the supervision of Professor Ciardelli and, then, as a PhD student (November 2022) under Professor Mattu.
His work has focused on developing and validating transport systems for small molecules and other chemotherapeutic agents to overcome biological barriers to delivery and increase treatment efficacy against brain tumours.
He is developing a spheroid-based model of glioblastoma capable of replicating the histological complexity of the tumour microenvironment. He is also optimizing the integration of this model with microfluidic platforms that replicate the vascular network of brain capillaries.
He is involved in the synthesis and characterization of nanoparticles for drug delivery. He is studying microglia cell-based transport systems to facilitate the penetration of nanomedicines through the blood-brain barrier and increase accumulation in glioblastoma.
He is co-supervising 2 master’s thesis students in collaboration with the Italian Institute of Genomic Medicine (IIGM) of Torino.
Skills
ERC sectors
SDG
Open badges
-
Percorso per i Giovani Talenti
Issued by Politecnico di Torino on 17-06-2022
Awards and Honors
- DMM Conference Travel Grant (CTG-DMM24031374) to attend the 7th Tissue Engineering and Regenerative Medicine International Society (TERMIS) World Congress. awarded by Disease Models & Mechanisms Journal and The Company of Biologists Limited (2024)
- TERMIS SYIS Scientific Excellence Award for the top scoring abstracts submitted by young researchers to the 7th TERMIS World Congress (2024)
- Award "Premio IPAM-Farmindustria 2023" for the best work on the application of the 3Rs principle in drug development and in the other fields of biomedical sciences. (2024)
- Best Oral Talk/Presentation Award by the Scientific Committee during the 1st Young Scientist Intersociety Webinar (2024)
- Award for the best oral presentation at the Research & Nanomedicine Workshop (Seventh Edition) at Pavia (2023)
- Supporting Grant for the 33rd Annual Conference of the European Society for Biomaterials (ESB 2023), awarded by the Società Italiana Biomateriali (2023)
Teaching
Teachings
Master of Science
- Formazione pratica in nanotecnologie biomediche e terapie avanzate. A.A. 2024/25, INGEGNERIA BIOMEDICA. Collaboratore del corso
- Bionanotecnologie. A.A. 2023/24, INGEGNERIA BIOMEDICA. Collaboratore del corso
Publications
Latest publications View all publications in Porto@Iris
- Bezze, Andrea; Mattioda, Carlotta; Ciardelli, Gianluca; Mattu, Clara (2024)
Harnessing cells to improve transport of nanomedicines. In: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 203. ISSN 0939-6411
Contributo su Rivista - Introvaia, Alessandra; Muccio, Sara; Bezze, Andrea; Mattu, Clara; Balestra, Gabriella (2024)
Automatic Segmentation of Multicellular Tumour Spheroids Images During Growing. In: European Federation for Medical Informatics Special Topic Conference (EFMI STC) 2024 - Collaboration across Disciplines for the Health of People, Animals and Ecosystems, Timisoara (RO), 27 to 29 November 2024, pp. 230-234. ISSN 0926-9630. ISBN: 9781643685540
Contributo in Atti di Convegno (Proceeding) - Bezze, Andrea; Muccio, Sara; Ciardelli, Gianluca; Mattu, Clara (2024)
Design of bioengineered glioblastoma microenvironment models for the validation of innovative nanomedicines. In: 7th TERMIS World Congress Seattle, Seattle (WA, US), June 25–28, 2024, pp. 168-168. ISSN 1937-3341
Contributo in Atti di Convegno (Proceeding) - Bezze, Andrea; Ciardelli, Gianluca; Mattu, Clara (2023)
In vitro human‐relevant glioblastoma models as the novel frontier of nanomedicine screening. In: CENTRO 3R IV ANNUAL MEETING: "The role of 3Rs in the age of One Health: where we are and where we’re going", Milano (IT), 13-15 settembre 2023, pp. 10-10. ISSN 2531-9892
Contributo in Atti di Convegno (Proceeding) - Bezze, Andrea; Ciardelli, Gianluca; Mattu, Clara (2023)
Hydrogel-based tumour microenvironments as models of vascularized Glioblastoma for validation of nanomedicines. In: 33rd Annual Conference of the European Society for Biomaterials - ESB 2023, Davos (CH), 4-8 settembre 2023, pp. 349-349. ISSN 2960-2483
Contributo in Atti di Convegno (Proceeding)