Anagrafe della ricerca

MITHoS - Multimodal Innovative THeranostic nanoSystem

36 mesi (2025)
Responsabile scientifico:
Tipo di progetto:
Ricerca Nazionale - PRIN
Ente finanziatore:
MINISTERO (Ministero dell'Università e della Ricerca)
Codice identificativo progetto:
Ruolo PoliTo:


Novel, smart, personalized early diagnosis and therapies are urgently needed to treat cancer, which still represents one of the major causes of death worldwide with an increasing trend. We propose to develop a Multimodal Innovative THeranostic nanoSystem (MITHoS) to cover the gap between the present anticancer nanomedicine tools and the clinical requirements. Despite the intense research development of nanotheranostic tools, the deal with the complexity of these multi-component nanostructures in the biological environment is still an open challenge. Nanotheranostic agents, which act at the same time for therapy and diagnosis, are based on the concerted actions of inorganic, organic and biological nanomaterials. Their effectiveness critically depends on the physico-chemical characteristics of their interfaces and on their behavior in physiological conditions and biological environment. When considering drug delivery nanosystems or therapeutic nanoparticles activated by the action of external stimuli, there is currently scarce understanding and control of the fundamental physical, chemical and biological processes that are involved. This gap of knowledge has so far impaired the translation of research efforts towards in vivo testing and finally to clinical practice. MITHoS will be a hybrid theranostic nanosystem: an ultra-sound responsive core-shell nanoparticle, coupled to a pharmaceutically-relevant anticancer cargo, embedded in a cell-derived lipid bilayer shell and finally equipped by targeting ligands. MITHoS will be validated against multiple myeloma, a tumor for which relapses and disease progressions are common among affected patients, owing to innate or acquired drug resistance. It will overcome the limitations of the current approaches with a bottom-up strategy: on the foundations of new, fundamental knowledge concerning nano/bio interfaces, we will build a finely tuned, multi-purpose and time-controlled theranostic nanotool against cancer. We will use cutting-edge molecular simulation techniques to characterize all the involved nano/bio interfaces and develop predictive computational tools for the guidance of the experimental investigations. At the same time, the experimental synthesis, characterization and test of the MITHoS nanosystem will evolve from simple, model systems to more complex nanostructures employing a variety of forefront techniques, from high resolution microscopy to X-ray and neutron scattering, until the final goal of in-vivo testing of the MITHoS system. Furthermore, novel methodologies for stimuli-responsive and remotely-controlled diagnosis and therapy will be developed. MITHoS concept will thus open new horizons in the nanomedicine field, proving how the synergic action of competences in the fields of physics, chemistry, material science, engineering, biophysics and biology can finally translate basic understanding into effective cancer treatment and overcome current barriers towards clinical translation.

Strutture coinvolte


  • POLITECNICO DI TORINO - Coordinatore

Parole chiave

Settori ERC

PE4_4 - Surface science and nanostructures
PE4_6 - Chemical physics
PE4_11 - Physical chemistry of biological systems

Obiettivi di Sviluppo Sostenibile (Sustainable Development Goals)

Obiettivo 3. Assicurare la salute e il benessere per tutti e per tutte le età


Costo totale progetto: € 574.233,00
Contributo totale progetto: € 474.233,00
Costo totale PoliTo: € 124.021,00
Contributo PoliTo: € 98.712,00