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Q-FENCE is a transformative initiative aimed at securing tomorrow’s digital infrastructure with quantum-resistant cryptography. In response to the rising threats posed by quantum computing, Q-FENCE develops a robust hybrid framework integrating classical, quantum, and post-quantum cryptographic techniques. Utilizing innovative approaches such as Ring-LWE, Module-LWE, Quantum Random Number Generators, and hardware-accelerated primitives, the project establishes a dual-layer security model that fortifies data protection across diverse infrastructures. Leveraging hardware-accelerated primitives and energy-efficient protocols, Q-FENCE ensures quantum resilience while addressing critical challenges such as seamless integration with legacy systems, regulatory compliance, and scalable deployment. By addressing key challenges like legacy system integration, interoperability, and regulatory compliance, it ensures a phased and seamless adoption across sectors including finance, healthcare, IoT, satellite and digital networks. Through sector-specific demonstrators, best-practice guidelines, and collaboration with EU policymakers, Q-FENCE bridges the gap between theoretical advancements and real-world applications, fostering digital sovereignty and resilience. Positioned as a critical player in the quantum-ready future, Q-FENCE not only safeguards sensitive data but also empowers stakeholders with practical, scalable, and innovative post-quantum solutions.