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REVEAL: The fiRst contrast medium in Electroencephalography for non-inVasivE intrAcraniaL and deep neuroimaging

Duration:
22/06/2026 - 30/06/2027
Principal investigator(s):
Project type:
Corporate-funded and donor-funded research
Funding body:
PRIVATI (Compagnia di San Paolo)
Project identification number:
ID 133332
PoliTo role:
Coordinator

Abstract

The project aims to bring to market a new non-invasive neuroimaging technology derived from the results of the EIC Pathfinder project CEREBRO. The core discovery, now protected through a patent filing, consists of the first contrast medium for electroencephalography capable of enriching the informational content of the EEG signal and increasing the ability to reconstruct deep and intracranial brain activity without resorting to invasive approaches. The underlying idea is that EEG should no longer be limited to passively recording the natural neuroelectric signal, but can instead be enhanced through an electrical contrast medium, the first of its kind, made of biocompatible nanodevices, capable of controllably modulating the electrical properties of the intracranial environment and generating new spectral components measurable from outside the body.

On this basis, the project intends to develop an integrated platform including the contrast medium, an external magnetic actuation system, EEG acquisition hardware, and dedicated signal processing and reconstruction algorithms. The technological objective is to demonstrate, in relevant environments and through an initial clinical validation, that the solution can overcome the limitations of conventional EEG in terms of spatial resolution and sensitivity to deep sources, while preserving the safety, non-invasiveness, and operational practicality required for future clinical use. The project also has a strong entrepreneurial dimension. The results will be valorized through the creation of a startup that will act as the main vehicle for industrial exploitation, while an industrial partner with consolidated expertise in EEG and neurotechnology will provide essential technical and business competences for system integration, product positioning, and the definition of the route to market. The project will therefore achieve not only technological maturation, but also a concrete transition toward investability, clinical validation, and the future commercialization of a radically new neurotechnology. The first applications under consideration include drugresistant epilepsy, functional mapping, and, in a longer-term perspective, advanced brain-computer interface platforms. In this way, the project is positioned at the intersection of biomedical research, medical devices, and high-value neurotechnology.

Structures

Keywords

Sustainable Development Goals

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Budget

Total cost: € 1.00
Total contribution: € 1.00
PoliTo total cost: € 1.00
PoliTo contribution: € 1.00