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The new emerging generation of microsystems represents a major opportunity for a substantial EU economic growth, in an industry counting already more than 200.000 workers and a turnover in 2019 of €450 billion. The Mesomorph concept provides the means to overcome the following 4 main hurdles:1. The intrinsic physic of microsystems doesn’t allow the simple downsizing of conventional technologies to industrialize micromanufacturing processes. Mesomorphallows to limit the number of micromanipulation tasks by integrating an all-in-onemachine featuring novel processes for the direct creation of functions (electronic, fluidic, optic) directly on a substrate, with a RESOLUTION down to 300nm, by combining multi-material addition (Two-Photon Polymerization, Atomic Layer 3D nano printing) and subtraction (Femtolaser micro-ablation) in a self-contained white room.2. Because of the intrinsic slowness of physical processes at microscale, productivity cannot be achieved by sequencing multiple single steps. Mesomorph proposes a scaleup throughput by PARALLELIZATION and batch processing UP TO 50k PARTS/YEAR, leveraging a new multiple micronozzles system to extend the SADALP working area from 10x10mm up to 500x500mm, and concurrently leveraging on the beam splitting technique of a high-power fs laser for ablation.3. Microsystems cannot be conceived with subcomponents. Mesomorph includes a specific Design-to-Lifevalue Platform to guide the development of new microsystems by fully exploiting the new processes.4. Innovation cannot be limited by the financial risk associated with the necessary investments. Mesomorph implements a new “Manufacturing as a Service” business model in which all the value chain’s actors can benefit from a positive net cash flow since production's start, effectively removing entry barriers for innovators.Mesomorph consortium is composed of 13 partners from 5 different countries. Each partner represents excellence in its own field.