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ExCISC – Exchange of Best Practices in Collaborative Intelligence for Safety-Critical Applications responds to the EU’s strategic agenda to strengthen Europe’s leadership in AI by promoting ethical, inclusive, and human-centric innovation. Aligned with the Industry 5.0 vision and the 2024 Trustworthy AI policy framework, ExCISC addresses the urgent need for interdisciplinary collaboration to develop AI systems that enhance—not replace—human decision-making in safety-critical domains. Building on the successful CISC MSCA ITN, which trained 14 Collaborative Intelligence Scientists and produced over 100 publications, ExCISC will expand this foundation through structured international, intersectoral, and interdisciplinary staff exchanges. The project focuses on real-world deployment of collaborative intelligence in industrial environments, integrating AI, robotics, human factors, neuroergonomics, system safety, cybersecurity, and ethical/legal expertise.