Fixed-term assistant professor
Department of Mechanical and Aerospace Engineering (DIMEAS)
Profile
Biography
During my PhD, I investigated the cellular and molecular mechanisms underlying microRNA-mediated cardiac regeneration, focusing on the biological processes involved in cardiac tissue repair. My research subsequently expanded to the development of physiologically relevant three-dimensional in vitro models for cardiac regeneration and the design of nanoparticle-based delivery systems for microRNAs and other therapeutic molecules, with the aim of advancing innovative regenerative medicine strategies. In 2024, I was awarded a Fondazione Umberto Veronesi Fellowship for a research project focused on the development of microRNA-based therapeutic approaches for esophageal cancer. As part of this project, I am developing advanced three-dimensional tumor models to investigate novel treatment strategies for advanced-stage esophageal cancer. My research combines expertise in bioengineering, cell and molecular biology, biomaterials, and nanomedicine to develop advanced experimental models and innovative therapeutic platforms for regenerative medicine and oncology. I collaborate on national and international research projects and contribute to teaching activities within the Master's Degree Program in Biomedical Engineering at Politecnico di Torino.
Scientific branch
(Area 0009 - Industrial and information engineering)
Awards and Honors
- SYIS 2022 - 3rd place "Best Oral presentation" conferred by TERMIS (2022)
- Premio conferito da GNB - Migliore tesi di dottorato "Massimo Grattarola" conferred by GNB (2023)
- Post-doctoral Fellowship Grant 2022 Fondazione Umberto Veronesi conferred by Fondazione Umberto Veronesi (2024)
Editorial boards
- CELLS (2026-), Guest Editor of magazine or editorial series
- FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2024-), Other editorial activities
Teaching
Collegi of the degree programmes
- Collegio di Ingegneria Biomedica. Componente invitato
Teachings
Master of Science
- Ingegneria per la medicina rigenerativa/Bioreattori (modulo di Ingegneria per la medicina rigenerativa). A.A. 2026/27, INGEGNERIA BIOMEDICA. Collaboratore del corso
- Laboratory of Tissues and Physiological Processes' Models. A.A. 2026/27, INGEGNERIA BIOMEDICA. Collaboratore del corso
- Ingegneria per la medicina rigenerativa/Bioreattori (modulo di Ingegneria per la medicina rigenerativa). A.A. 2025/26, INGEGNERIA BIOMEDICA. Collaboratore del corso
- Laboratory of Tissues and Physiological Processes' Models. A.A. 2025/26, INGEGNERIA BIOMEDICA. Collaboratore del corso
- Ingegneria per la medicina rigenerativa/Bioreattori (modulo di Ingegneria per la medicina rigenerativa). A.A. 2024/25, INGEGNERIA BIOMEDICA. Collaboratore del corso
- Laboratory of Tissues and Physiological Processes' Models. A.A. 2024/25, INGEGNERIA BIOMEDICA. Collaboratore del corso
- Ingegneria per la medicina rigenerativa/Bioreattori (modulo di Ingegneria per la medicina rigenerativa). A.A. 2023/24, INGEGNERIA BIOMEDICA. Collaboratore del corso
- Laboratory of Tissues and Physiological Processes' Models. A.A. 2023/24, INGEGNERIA BIOMEDICA. Collaboratore del corso
- Ingegneria per la medicina rigenerativa/Bioreattori (modulo di Ingegneria per la medicina rigenerativa). A.A. 2022/23, INGEGNERIA BIOMEDICA. Collaboratore del corso
- Formazione pratica in nanotecnologie biomediche e terapie avanzate. A.A. 2022/23, INGEGNERIA BIOMEDICA. Collaboratore del corso
- Ingegneria per la medicina rigenerativa. A.A. 2021/22, INGEGNERIA BIOMEDICA. Collaboratore del corso
- Formazione pratica in nanotecnologie biomediche e terapie avanzate. A.A. 2021/22, INGEGNERIA BIOMEDICA. Collaboratore del corso
- Ingegneria per la medicina rigenerativa. A.A. 2020/21, INGEGNERIA BIOMEDICA. Collaboratore del corso
- Formazione pratica in nanotecnologie biomediche e terapie avanzate. A.A. 2020/21, INGEGNERIA BIOMEDICA. Collaboratore del corso
Research
Research groups
Research projects
Projects funded by competitive calls
- REVOLUTION - Unlocking new frontiers in RNA therapies through functionalized polymer lipid hybrid nanoparticles, (2026-2026) - Componente gruppo di Ricerca
Corporate-funded and donor-funded research - NAPTER - Nanoparticelle polimeriche ibride per una terapia con RNA nella cura di patologie cardiache: scale-up della produzione e validazione preclinica (NAPTER), (2023-2025) - Componente gruppo di Ricerca
PNRR – Mission 4
Publications
PoliTO co-authors
Last years publications
Publications by type
Latest publications View all publications in Porto@Iris
- Coletto, Martina; Paoletti, Camilla; Nicoletti, Letizia; Marcello, Elena; Stola, ... (2026)
Innovative RNA transfection kit based on hybrid polymer–lipid nanoparticles. In: TISSUE ENGINEERING, PART A, vol. 32, pp. 15-16. ISSN 1937-3341
Contributo su Rivista - Coletto, Martina; Paoletti, Camilla; Nicoletti, Letizia; Stola, Giovanni Paolo; Mattu, ... (2026)
Hybrid Nanoparticles Enable Targeted Cardiac Regeneration via microRNA Delivery. In: 5th Edition Conference on Global Nanotechnology #NanoSeries2026, Torino (IT), June 15-17, 2026, pp. 170-170
Contributo in Atti di Convegno (Proceeding) - Coletto, Martina; Paoletti, Camilla; Nicoletti, Letizia; Stola, Giovanni Paolo; ... (2026)
Functionalized hybrid nanoparticles loaded with microRNA for targeting fibroblasts and cardiomyocytes in cardiac regeneration. In: ESC Fund - Basic Cardiovascular Science Course 2026, Nice (FR), June 10-14, 2026
Contributo in Atti di Convegno (Proceeding) - Nicoletti, Letizia; Coletto, Martina; Schiavone, Francesco; Ruocco, Gerardina; Stola, ... (2026)
Hybrid nanoparticles for targeted cardiac regeneration via microRNA delivery. In: 14th Galenus International Workshop "RNA Therapeutics: Taking Stock and Glimpse into the Future", Napoli, 18 - 19 maggio 2026, pp. 22-22
Contributo in Atti di Convegno (Proceeding) - Tivano, Francesca; Marcello, Elena; Paoletti, Camilla; Zoso, Alice; Mattu, Clara; ... (2026)
Injectable self-healing oxidized pectin and carbohydrazide-modified gelatin hydrogels for curcumin-loaded zein nanoparticle delivery in antioxidant therapy. In: BIOMATERIALS SCIENCE, vol. 14, pp. 1559-1581. ISSN 2047-4830
Contributo su Rivista - Ruocco, Gerardina; Nicoletti, Letizia; Coletto, Martina; Toccaceli, Alessia; Chiono, ... (2026)
ECM proteins regulate microRNA-mediated direct reprogramming of fibroblasts into cardiomyocytes via YAP signaling. In: FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, vol. 14. ISSN 2296-4185
Contributo su Rivista - Ruocco, Gerardina; Marcello, Elena; Paoletti, Camilla; Salvi, Massimo; Zoso, Alice; ... (2026)
Fibrous bioinks for the bioprinting of anisotropic scaffolds with micro-and nanoscale organization as a novel approach for in vitro skeletal muscle engineering. In: INTERNATIONAL JOURNAL OF BIOPRINTING, vol. 12, pp. 323-347. ISSN 2424-8002
Contributo su Rivista - Nicoletti, L.; Coletto, M.; Stola, G. P.; Paoletti, C.; Marcello, E.; Testore, D.; ... (2025)
Strategies for the delivery of RNA therapeutics to diseased heart tissue. In: EXPERT OPINION ON DRUG DELIVERY, vol. 22, pp. 1583-1598. ISSN 1744-7593
Contributo su Rivista - Marcello, Elena; Tivano, Francesca; Stola, Giovanni Paolo; Nicoletti, Letizia; Paoletti, ... (2025)
Design and validation of a hydrogel-based advanced delivery system for cardiac regeneration after myocardial infarction. In: Next Gen3Ration Research, Genova, 18-19 Settembre 2025
Contributo in Atti di Convegno (Proceeding) - Tivano, Francesca; Marcello, Elena; Paoletti, Camilla; Mattu, Clara; Carmagnola, Irene; ... (2025)
Sustainable Self-Healing Pectin-Based Hydrogels for Controlled Release of Curcumin-Loaded Zein Nanoparticles for Antioxidant Wound Treatment. In: 34th Annual Conference of the European Society for Biomaterials, Turin, 7-11 Settembre 2025
Contributo in Atti di Convegno (Proceeding) - Zoso, Alice; Tivano, Francesca; Marcello, Elena; Paoletti, Camilla; Damonte, Giorgia; ... (2025)
Green injectable pectin-based hydrogels for controlled release of EVs for cardiac fibrosis treatment. In: 34th Annual Conference of the European Society for Biomaterials, Turin, 7-11 Settembre 2025
Contributo in Atti di Convegno (Proceeding) - Ballerini, Mattia; Tivano, Francesca; Marcello, Elena; Paoletti, Camilla; Mattu, Clara; ... (2025)
Development of pathological Heart-on-Chip models to improve Extracellular Vesicle-based paracrine therapy against myocardial injury. In: 33rd Annual Conference of the European Society for Biomaterials, Turin, 7-11 Settembre 2025
Contributo in Atti di Convegno (Proceeding) - Coletto, Martina; Paoletti, Camilla; Nicoletti, Letizia; Stola, Giovanni Paolo; Mattu, ... (2025)
Innovative hybrid polymer-lipid nanoparticles for targeted microRNAs-based cardiac regeneration. In: 34TH ANNUAL CONFERENCE OF THE EUROPEAN SOCIETY FOR BIOMATERIALS, Torino (IT), September 7-11, 2025
Contributo in Atti di Convegno (Proceeding) - Coletto, Martina; Nicoletti, Letizia; Paoletti, Camilla; Marcello, Elena; Stola, ... (2025)
Hybrid polymer-lipid nanoparticles as innovative transfection vectors for microRNA delivery. In: Controlled Release Society (CRS) 2025 Annual Meeting and Exposition, Philadelphia (USA), July 14-18, 2025
Contributo in Atti di Convegno (Proceeding) - Stola, Giovanni Paolo; Nicoletti, Letizia; Coletto, Martina; De Carolis, Martina; ... (2025)
Development of Functionalized Polymer-Lipid Hybrid Nanoparticles for Skeletal Muscle-Targeted RNA Delivery in Spinal and Bulbar Muscular Atrophy (SBMA) Therapy. In: TISSUE ENGINEERING. PART A, vol. 31, pp. 21-22. ISSN 1937-335X
Contributo su Rivista - Schiavone, Francesco; Nicoletti, Letizia; Paoletti, Camilla; Coletto, Martina; Marcello, ... (2025)
Lyophilization Strategies Enhancing the Storage Stability of RNA-loaded Nanoparticles. In: 34TH ANNUAL CONFERENCE OF THE EUROPEAN SOCIETY FOR BIOMATERIALS, Torino (IT), September 7-11, 2025
Contributo in Atti di Convegno (Proceeding) - Ruocco, Gerardina; Marcello, Elena; Paoletti, Camilla; Zoso, Alice; Carmagnola, Irene; ... (2024)
"Engineered fiber-based anisotropic microenvironments for 2D and 3D in vitro models of skeletal muscle tissues". In: SIB2024-Faenza
Contributo in Atti di Convegno (Proceeding) - Ruocco, Gerardina; Marcello, Elena; Paoletti, Camilla; Zoso, Alice; Carmagnola, Irene; ... (2024)
Engineered fiber-based anisotropic microenvironments for 2D and 3D in vitro models of skeletal muscle tissues. In: 2024 European Congress on Alternatives to Animal Testing, Linz (AUT), September 18 – 20, pp. 1-178
Contributo in Atti di Convegno (Proceeding) - Tivano, Francesca; Marcello, Elena; Paoletti, Camilla; Nicoletti, Letizia; Mattioda, ... (2023)
Green nanomedicine and sustainable drug-releasing systems for regenerative medicine. In: CONGRESSO NAZIONALE SOCIETA’ ITALIANA BIOMATERIALI, Camerino, Italia, 3-6 Luglio 2023
Contributo in Atti di Convegno (Proceeding) - Tivano, Francesca; Marcello, Elena; Paoletti, Camilla; Nicoletti, Letizia; Mattioda, ... (2023)
Green nanomedicine and sustainable drug-releasing systems for regenerative medicine. In: 33rd Annual Conference of the European Society for Biomaterials, Davos, Switzerland, 4-8 Settembre 2023, pp. 62-62
Contributo in Atti di Convegno (Proceeding)
Knowledge Valorisation
Technology transfer
- Metodo per la preparazione di nanoparticelle polimeriche ibride per il rilascio di farmaci oligonucleotidici nella terapie farmacologiche a scopo rigenerativo, curativo e preventivo.. national and international Patent
Inventors: Valeria Chiono Clara Mattu Letizia Nicoletti Camilla Paoletti