Ph.D. in Bioingegneria E Scienze Medico-chirurgiche , 37th cycle (2021-2024)
Ph.D. obtained in 2025
Dissertation:
Design, Development and Regulatory Assessment of an Innovative Low-Oxygen CPAP System- AliseO2
Tutors:
Umberto Morbiducci Alberto Audenino
Research presentation:
PosterProfile
Research topic
Characterisation of innovative noninvasive closed-loop ventilation circuit for CPAP therapy delivery
Research interests
Biography
Her first approach to the research world was during her master's degree thesis project at the Rizzoli Orthopaedic Institute, in Bologna.
The project concerned the implementation and validation of a protocol for the mechanical characterisation of articular cartilage by indentation of the osteochondral complex.
After this thesis work, in January 2022, Margherita De Luca started her PhD at the Polytechnic of Turin in collaboration with a Piedmontese company.
The PhD project concerns the design, characterisation and development of an innovative non invasive closed-loop ventilation circuit that delivers CPAP (continuous positive airway pressure) therapy, with the final goal of industrialising and commercialising this medical device. CPAP therapy is widely used to treat patients with hypoxemic respiratory failure to avoid the necessity of intensive care.
Teaching
Teachings
Master of Science
- Challenge@PoliTo by Students - Silver Economy. A.A. 2022/23, INGEGNERIA GESTIONALE (ENGINEERING AND MANAGEMENT). Collaboratore del corso
- Innovations in cardiovascular and respiratory engineering. A.A. 2023/24, INGEGNERIA BIOMEDICA. Collaboratore del corso
- Progettazione di protesi e organi artificiali. A.A. 2024/25, INGEGNERIA BIOMEDICA. Collaboratore del corso
Research
Research groups
Publications
Works published during the Ph.D. View all publications in Porto@Iris
- De Luca, Margherita; Formaggio, Andrea; Terzini, Mara; Borrelli, Simone; Putame, ... (2025)
Impact of circuit configuration on the mechanical performance of CPAP therapy devices: an experimental study. In: FRONTIERS IN MEDICAL TECHNOLOGY, vol. 7. ISSN 2673-3129
Contributo su Rivista - Formaggio, Andrea; Luca, Margherita De; Borrelli, Simone; Putame, Giovanni; Vita, Nello ... (2025)
A multidomain 0D model for continuous positive airway pressure ventilation circuit design: Validation and applications. In: BIOCYBERNETICS AND BIOMEDICAL ENGINEERING, vol. 45, pp. 170-180. ISSN 0208-5216
Contributo su Rivista - De Luca, Margherita; Formaggio, Andrea; Terzini, Mara; Putame, Giovanni; Olivieri, ... (2025)
Experimental assessment of CO2 rebreathing in closed-circuit CPAP therapy with different non-invasive interfaces. In: JOURNAL OF BIOMECHANICS, vol. 189, pp. 1-7. ISSN 1873-2380
Contributo su Rivista - De Luca, Margherita; Formaggio, Andrea; Putame, Giovanni; Borrelli, Simone; Terzini, ... (2024)
Experimental investigation of rebreathing phenomenon in non-invasive ventilation interfaces. In: 29th Congress of the European Society of Biomechanics, Edinburgh (Scotland), June 30 – July 3, 2024
Contributo in Atti di Convegno (Proceeding) - Formaggio, A.; De Luca, M.; Putame, G.; Borrelli, S.; Audenino, A. L.; Terzini, M. (2023)
In silico simulations of lung recruitment in patients ventilated with an innovative device for CPAP therapy.. In: XII Annual Meeting of the Italian Chapter of the European Society of Biomechanics, Torino (Italy), 18-19 Settembre, pp. 1-1
Contributo in Atti di Convegno (Proceeding) - Formaggio, A.; De Luca, M.; Putame, G.; Borrelli, S.; Audenino, A. L.; Terzini, M. (2023)
CFD simulations of the CO2 rebreathing in different helmet-like interfaces for the CPAP therapy delivery.. In: 28th Congress of the European Society of Biomechanics, Maastricht (Netherlands), 9-12 Luglio, pp. 1-1
Contributo in Atti di Convegno (Proceeding) - De Luca, Margherita; Formaggio, Andrea; Putame, Giovanni; Borrelli, Simone; Audenino, ... (2023)
Experimental comparison of pressure performances in different CPAP delivery techniques. In: 28th Congress of the European Society of Biomechanics, Maastricht (Netherlands), 9-12 Luglio
Contributo in Atti di Convegno (Proceeding) - De Luca, Margherita; Formaggio, Andrea; Putame, Giovanni; Borrelli, Simone; Audenino, ... (2023)
Experimental pressure comparison of commercial cpap devices: preliminary investigation of target performance. In: XII Annual Meeting of the Italian Chapter of the European Society of Biomechanics, Torino (IT), 18-19 Settembre
Contributo in Atti di Convegno (Proceeding) - Formaggio, Andrea; De Luca, Margherita; Putame, Giovanni; Borrelli, Simone; Audenino, ... (2022)
Experimental and computational simulation of a non-invasive closed-loop breathing circuit. In: ESB-ITA 2022, XI Annual Meeting, Massa (Italy)
Contributo in Atti di Convegno (Proceeding)